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Journal of the Korean Society of Pediatric Nephrology 2008;12(2): 143-149. doi: https://doi.org/10.3339/jkspn.2008.12.2.143
다양한 신장질환 환아들에서 요중 N-Acetyl-beta-D-Glucosamini dase와 beta 2-Microglobulin
윤소진, 신재일, 이재승, 김현숙
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4연세대학교 의과대학 진단검사의학교실
Urinary N-Acetyl-beta-D-Glucosaminidase and beta 2-Microglobulin in Children with Various Renal Diseases
So-Jin Yoon, Jae-Il Shin, Jae-Seung Lee, Hyon-Suk Kim
1The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Children s Hospital
2The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Children s Hospital
3The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Children s Hospital
4The Institute of Kidney Disease, Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Children s Hospital
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ABSTRACT
Purpose : Urinary N-acetyl-beta-D-glucosaminidase(NAG) and beta 2-microglobulin(B2M) is considered to be a marker of tubulointerstitial injury. The aim of this study was to examine the urinary levels of NAG and B2M in children with various renal diseases.
Methods : We studied 21 children(8.9$pm$4.5 years, Male:Female=14:7) and they were divided into three groups: group I(steroid-sensitive nephrotic syndrome-4 patients), group II(various kinds of glomerulonephritis-4 patients), and group III(normal urinalysis or non-glomerular renal diseases-13 patients).
Results : Urinary NAG levels in groups I and II were significantly higher than those in group III(19.4$pm$11.5 and 30.0$pm$30.1 vs. 4.7$pm$3.9, P=0.01), while urinary B2M levels did not differ among the 3 groups, although urinary NAG levels were positively correlated with urinary B2M levels(r=0.49, P=0.03). Urinary NAG and B2M levels were all correlated with proteinuria(r=0.79, P<0.001 and r=0.68, respectively, P=0.001) serum albumin(r=-0.72, P<0.001 and r=-0.57, respectively, P=0.01) and cholesterol(r=0.58, P=0.006 and r=0.56, respectively, P=0.013) levels.
Conclusions : Urinary excretions of NAG and B2M are increased in children with steroidsensitive nephrotic syndrome and various kinds of glomerulonephritis, suggesting tubular dysfunction might be present in these diseases.
Key words: N-acetyl-beta-D-glucosaminidase | Beta 2-microglobulin | Tubulointerstitial injury | Children
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