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Journal of the Korean Society of Pediatric Nephrology 1999;3(1): 64-71.
저단백식이의 투여가 만성신부전증의 진행에 미치는 영향에 관한 실험적 연구
김교순, 김기혁, 김상윤, 강용주, 맹원재
1건국대학교 의과대학 소아과학교실
2건국대학교 의과대학 해부병리학교실 및 건국대학교 축산대학 사료영양학과
3건국대학교 의과대학 해부병리학교실 및 건국대학교 축산대학 사료영양학과
4건국대학교 의과대학 해부병리학교실 및 건국대학교 축산대학 사료영양학과
5건국대학교 의과대학 해부병리학교실 및 건국대학교 축산대학 사료영양학과
Effects of Dietary Protein on the Progression of Early Chronic Renal Failure in Subtotally Nephrectomizid Rats
Kyo-Sun Kim, Kee-Hyuk Kim, Sang-Yun Kim, Yong-Joo Kang, Won-Jae Maeng
1Dept. of Pediatrics, KonKuk University, College of Medicine
2Dept. of College of medicine and Dept. of Feed and Nutritional Science, KonKuk University, College of Animal Husbandry
3Dept. of College of medicine and Dept. of Feed and Nutritional Science, KonKuk University, College of Animal Husbandry
4Dept. of College of medicine and Dept. of Feed and Nutritional Science, KonKuk University, College of Animal Husbandry
5Dept. of College of medicine and Dept. of Feed and Nutritional Science, KonKuk University, College of Animal Husbandry
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ABSTRACT
Purpose : The protective effects of dietary protein on the progression of renal failure were studied in subtotally nephrectomized rats.
Methods : Treatment groups were as follows; 5/6 nephrectomy and a normal protein ($18.5%$) diet (NP); 5/6 nephrectomy and a low protein ($6%$) diet (LP): 5/6 nephrectomy, a normal protein diet and converting enzyme inhibitor, enalapril (NPE): 5/6 nephrectomy, a low protein diet and enalapril (LPE). Both diets were isocaloric and had the same phosphorus content. Proteinuria, remnant kidney weight, mesangial matrix expansion score and glomerular volume were assessed at 4, 12 and 16 weeks after renal ablation.
Results : LP and NP developed progressive hypertension. Eight weeks after surgery, LPE and NPE controlled hypertension. LP, LPE, and NPE had significantly less proteinuria than NP at 16 weeks (P<0.05). Kidney weight in LP were markedly less enlarged than NP (P<0.05). There was no difference in kidney weight between LPE and NPE. At 12 and 16 weeks the mesangial matrix expansion score was significantly less in LP, LPE, and NPE compared to NP (P<0.05). At 12 and 16 weeks mean glomerular volume was significantly less in LP compared to NP (P<0.05). At 12 and 16 weeks mean glomerular volume in LPE was significantly less compared to NPE.
Conclusion : Dietary protein restriction afforded considerable protection from renal injury in the rat remnant kidney model. During the enalapril treatment, there was no additional protective effect of dietary protein restriction against the development of renal lesions.
Key words: Chronic renal failure | Dietary protein restriction | Converting enzyme inhibitor | Remnant kidney model
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