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Journal of the Korean Society of Pediatric Nephrology 1998;2(2): 125-132.
저단백 식이 및 항고혈압제의 투여가 만성신부전증의 진행에 미치는 영향에 관한 실험적 연구
김교순, 김기혁, 김상윤, 강용주, 맹원재
1건국대학교 의과대학 소아과학교실
2건국대학교 의과대학 소아과학교실
3건국대학교 의과대학 해부병리학교실
4건국대학교 축산대학 사료영양학과
5건국대학교 축산대학 사료영양학과
Renal Effects of a Low Protein Diet and Antihypertensive Drugs on the Progression of Early Chronic Renal Failure in 5/6 Nephrectomized Rats
Kyo-Sun Kim, Kee-Hyuk Kim, Sang-Yun Kim, Yong-Joo Kang, Won-Jae Maeng
1Dept. of Pediatrics, College of Medicine, KonKuk University
2Dept. of Pediatrics, College of Medicine, KonKuk University
3Dept. of Pathology, College of Medicine, KonKuk University
4Dept. of Feed and Nutritional Science, College of Animal Husbandry, KonKuk University
5Dept. of Feed and Nutritional Science, College of Animal Husbandry, KonKuk University
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ABSTRACT
Purpose : To study whether a low protein diet increase the efficacy of antihypertensive therapy on the progression of renal failure, we conducted an experimental study using 5/6 nephrectomized rats(n=63).
Methods : At 7 days after surgery, rats were randomly assigned to three groups according to receiving antihypertensive drug: no antihypertensive drug (U), enalapril (E), and nicardipine (N), respectively and fed a low protein diet (6$%$ protein). Proteinuria, mesangial matrix expansion score and glomerular volume were assessed at 4, 12 and 16 weeks after renal ablation.
Results : Group U rats on a low protein diet developed progressive hypertension ($140{pm}8,;162{pm}5,;171{pm}5;and;184{pm}11;mmHg$ at 4, 8, 12 and 16 weeks) which were controlled by E and N. Group U rats on a low protein diet developed proteinuria ($74{pm}15;mg/day$ at 16 weeks) which were decreased by E ($42{pm}12 mg/day$) or N ($48{pm}8 mg/day$) (p<0.05). Mesangial matrix expansion score and glomerular volume were not different between groups U, E and N on a low protein diet regardless of the antihypertensive drugs administered.
Conclusion : A low protein diet did not affect blood pressure. Enalapril and nicardipine-treated rats on a low protein diet did not have different mesangial matrix expansion and glomerular volumes from rats on a low protein diet at 12 weeks and 16 weeks, in spite of the better controlling of systemic hypertension and lessening of proteinuria. Thus, combined treatment with a low protein diet and antihypertensive drugs didn't appear to show any addition,11 effects to attenuate glomerular injury.
Key words: Chronic renal failure | A low protein diet | Antihypertensive drugs | Remnant kidney model
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