J Korean Soc Pediatr Nephrol > Volume 15(1); 2011 > Article
J Korean Soc Pediatr Nephrol 2011;15(1): 76-80. doi: https://doi.org/10.3339/jkspn.2010.15.1.76
신 이식 후 소장 파열을 초래한 후기 cytomegalovirus 질환
이희우, 한혜원, 박영서
1을지대학교 의과대학 소아청소년과
2을지대학교 의과대학 소아청소년과
3울산대학교 의과대학 서울아산병원 소아청소년과
Late Cytomegalovirus Disease Causes Ileal Perforation after Kidney trasplantation
Hee-Woo Lee, Hye-Won Hahn, Young-Seo Park
1Department of Pediatrics, Eulji University School of Medicine
2Department of Pediatrics, Eulji University School of Medicine
3Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine
Received: October 26, 2010;  Accepted: January 31, 2011.
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Cytomegalovirus (CMV) is the single most common infection following kidney transplantation and despite prophylactic strategies and the development of new antiviral agents, it still remains a cause of considerable morbidity and mortality. Current literature suggests that CMV infection may trigger rejection. We report a case of late CMV disease in a preemptive seropositive recipient who did not receive CMV prophylaxis. Diarrhea and abdominal cramping persisted after the administration of mycophenolate mofetil (MMF) six months after transplantation and resulted in ileal perforation at eight months after transplantation. The boy recovered after six weeks of treatment with ganciclovir. MMF has been mooted as a risk factor for CMV infection since its introduction, and further investigations are required to confirm its role. More attention to infectious complications is necessary and serial monitoring of viral load is recommended when MMF is administered.
Key words: Cytomegalovirus | Kidney transplantation | Ileal perforation
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