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Journal of the Korean Society of Pediatric Nephrology 2005;9(2): 167-174.
소아 스테로이드 반응성 신증후군에서 재발과 관련된 예측인자
조민현, 이동원, 이태호, 고철우
1포천중문의과대학교 구미차병원 소아과
2경북대학교 의과대학 소아과학교실
3경북대학교 의과대학 소아과학교실
4경북대학교 의과대학 소아과학교실
Predictive factors for Relapse in Children with Steroid Responsive Nephrotic Syndrome
Min Hyun Cho, Dong Won Lee, Tae Ho Lee, Cheol Woo Ko
1Department of Pediatrics, College of Medicine, Pochon CHA University, Kumi CHA Medical Center
2Department of Pediatrics, College of Medicine, Kyungpook National University
3Department of Pediatrics, College of Medicine, Kyungpook National University
4Department of Pediatrics, College of Medicine, Kyungpook National University
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Purpose : Relapses are a major problem in children with steroid responsive nephrotic syndrome(SRNS). This study has been performed to determine the predictive factors for relapse in children with SRNS.
Methods : The study group consisted of 7,3 children with SRNS who had been admitted to the Department of Pediatrics, Kyungpook National University Hospital, over 6 years from 1996 to 2001. The medical records were reviewed retrospectively and analyzed to determine significant relationships between selected variables[age at onset, sex, laboratory data, the rapidity of response(days to remission), interval to first relapse] and the frequency of relapse.
Results : The age($mean{pm}SD$) of patients was $4.53{pm}2.53$ years old. The male to female ratio was 52:21. In 95$%$, 39 out of the 41 children had a renal biopsy, and the final diagnosis was minimal change nephrotic syndrome. There was no significant correlation between the frequency of relapse and the following variables age at onset, sex, and presence of hematuria. However, the rapidity of response correlated well with the frequency of relapse, especially during the first year after the onset of the disease(P=0.005).
Conclusion : The rapidity of response is expected to be one of the predictive (actors for relapse in children with SRNS. (J Korean Soc Pediatr Nephrol 2005;9:167-174)
Key words: Steroid responsive nephrotic syndrome | Predictive factors | Relapse
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