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Journal of the Korean Society of Pediatric Nephrology 2002;6(1): 123-130.
소아에서 신이식후 발생한 Posttransplant Lymphoproliferative Disease(PTLD) 1례
은병욱, 박은실, 이성용, 한혜원, 장주영, 박경미, 김철우, 강진한, 고재성, 하일수, 이환종, 정해일, 서정기
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실
6서울대학교 의과대학 소아과학교실
7서울대학교 의과대학 병리학 교실
8가톨릭대학교 의과대학 소아과학교실
9서울대학교 의과대학 소아과학교실
10서울대학교 의과대학 소아과학교실
11서울대학교 의과대학 소아과학교실
12서울대학교 의과대학 소아과학교실
13서울대학교 의과대학 소아과학교실
A Case of Posttransplant Lymphoproliferative Disease(PTLD) Following Renal Transplantation in a Child
Byung-Wook Eun, Eun-Sil Park, Seong-Yong Lee, Hye-Won Hahn, Ju-Young Jang, Kyung-Mi Park, Chul-Woo Kim, Gin-Han Kang, Jae-Seong Ko, Il-Soo Ha, Hoan-Jong Lee, Hae-Il Cheong, Jeong-Kee Seo
1Department of Pediatrics, Seoul National University, College of Medicine
2Department of Pediatrics, Seoul National University, College of Medicine
3Department of Pediatrics, Seoul National University, College of Medicine
4Department of Pediatrics, Seoul National University, College of Medicine
5Department of Pediatrics, Seoul National University, College of Medicine
6Department of Pediatrics, Seoul National University, College of Medicine
7Department of Pathology, Seoul National University, College of Medicine
8Department of Pediatrics, The Catholic University, College of Medicine
9Department of Pediatrics, Seoul National University, College of Medicine
10Department of Pediatrics, Seoul National University, College of Medicine
11Department of Pediatrics, Seoul National University, College of Medicine
12Department of Pediatrics, Seoul National University, College of Medicine
13Department of Pediatrics, Seoul National University, College of Medicine
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ABSTRACT
Posttransplant lymphoproliferative disease (PTLD) represents a diverse lymphoproliferative disorder ranging front nonspecific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus (EBV) infection and high dose immunosuppression. PTLD after renal transplantation was reported at first in adult in Korea in 1997. In children there have been several cases of PTLD after liver transplantation but PTLD after renal transplantation has not been reported. This is a case report of PTLD developed 4 months after renal transplantation in a 9-year-old boy. The major clinical manifestations were fever, multiple lymph nodes enlargement and blood-tinged stool. EBV was detected by in-situ hybridization in the enlarged cervical lymph node and the colonic tissue. Histological examination revealed B-cell lineage. Use of ganciclovir and reduction of the immunosuppression level resulted in complete remission of PTLD. This is the first pediatric case report of PTLD following renal transplantation in Korea. (J Korean Soc Pediatr Nephrol 2002 ; 6 : 123-30)
Key words: Posttransplant lymphoproliferative disorder | Renal transplantation | Child
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