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Journal of the Korean Society of Pediatric Nephrology 2000;4(1): 11-16.
소아에서 소변 Na/K 비를 통한 칼슘 배설량 예측
고한성, 최정훈, 최병민, 유기환, 홍영숙, 이주원, 김순겸
1고려대학교 의과대학 소아과학 교실
2고려대학교 의과대학 소아과학 교실
3고려대학교 의과대학 소아과학 교실
4고려대학교 의과대학 소아과학 교실
5고려대학교 의과대학 소아과학 교실
6고려대학교 의과대학 소아과학 교실
7고려대학교 의과대학 소아과학 교실
A Study on Method for Screening of Hypercalciuria in Children
Han Seong Ko, Jeong Hoon Choi, Byoung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
1Department of Pediatrics, Korea University, College of Medicine
2Department of Pediatrics, Korea University, College of Medicine
3Department of Pediatrics, Korea University, College of Medicine
4Department of Pediatrics, Korea University, College of Medicine
5Department of Pediatrics, Korea University, College of Medicine
6Department of Pediatrics, Korea University, College of Medicine
7Department of Pediatrics, Korea University, College of Medicine
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ABSTRACT
Purpose. Urinary calcium excretion using a 24-hr urine colledtion has been used for the diagnosis of hypercalciuria up to now. But It takes a lot of time and costs much. We have investigated on a more simple method for screening of hypercalciuria in children.
Methods: We had retrospectively analyzed sodium, potassium, calcium and creatinine in spot urine of eighty-four patients with urinary symptoms from May 1998 to July 1998 in Korea university Guro hospital and compared the urinary Ca/Cr ratio with the Nin ratio. Using a urinary Nan ratio >2.68 as a cutoff value in predicting the occurrence of hypercalciuria, we measured its sensitivity, specificity, positive predictive value and the negative predictive value.
Results : A direct relationship was found between urinary Na/K and Ca/Cr ratio (r=0.496, P<0.001, Ca/Cr : Na/K x 0.0167+0.061). Using a urinary Na/K ratio >2.68 as a cutoff value in predicting the occurrence of hypercalciuria, its sensitivity was found to be $100%$ and its specificity $54.5%$. The positive predictive value was $37.5%$ and the negative predictive value $100%$.
Conclusions : Spot urine Na/K ratio is a valuable test for the screening of hypercalciuria in children.
Key words: Screening of hypercalciuria | Urinary Ca/Cr ratio | Urinary Na/K ratio
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