A New Reference Range of Serum Anion Gap

Shin, Young-Ju; Cheon, Hae-Won; Choi, Byung-Min; Yoo, Kee-Hwan; Hong, Young-Sook; Lee, Joo-Won; Kim, Soon-Kyum

J Korean Soc Pediatr Nephrol > Volume 2(1); 1998 > Article

J Korean Soc Pediatr Nephrol 1998;2(1): 9-13.

혈청 Anion gap의 새로운 범위에 관한 연구

신영주, 전혜원, 최병민, 유기환, 홍영숙, 이주원, 김순겸

¹고려대학교 의과대학 소아과
²고려대학교 의과대학 소아과
³고려대학교 의과대학 소아과
⁴고려대학교 의과대학 소아과
⁵고려대학교 의과대학 소아과
⁶고려대학교 의과대학 소아과
⁷고려대학교 의과대학 소아과

A New Reference Range of Serum Anion Gap

Young-Ju Shin, Hae-Won Cheon, Byung-Min Choi, Kee-Hwan Yoo, Young-Sook Hong, Joo-Won Lee, Soon-Kyum Kim

¹Department of Pediatrics, Korea University, College of Medicine
²Department of Pediatrics, Korea University, College of Medicine
³Department of Pediatrics, Korea University, College of Medicine
⁴Department of Pediatrics, Korea University, College of Medicine
⁵Department of Pediatrics, Korea University, College of Medicine
⁶Department of Pediatrics, Korea University, College of Medicine
⁷Department of Pediatrics, Korea University, College of Medicine

ABSTRACT

Purpose: The old reference range of serum anion gap(AG) may be excessive compared with value measured by new electrolyte analyzers. Therefore, we studied to establish a new reference range of AG using an autoanalyzer.
Methods: With the use of analyzer(Hitachi 747 by enzymatic methods), serum Na and Cl were measured, and with the use of analyzer(CX-3 by differental rage pH), serum $TCO_2$ was measured. We measured AG(=Na-($Cl+HCO_3$)) in 395 stable patients with normal serum albumin and creatinine levels of the pediatric in-patients and out-patients for preoperative examination from march 1997 to July 1997.
Results : The normal serum$ AG(mean{pm}SD)$ were neonate, $11.2{pm}3.2$ mEq/L; infancy, $11.8{pm}2.7$ mEq/L; early childhood, $12{pm}2.7$ mEq/L; late childhood, $11.7{pm}3.2$ mEq/L; adolescence, $9.6{pm}2.7$ mEq/L; adult, $9.0{pm}2.7$ mEq/L. Normal serum AG in more than 10 years of age was significantly lower than the previous normal value and also the difference of AG between more than 10 years and less than 10 years was statistically significant(P<0.05).
Conclusions : We suggest to measure serum AG according to each type of analyzers.

Key words: serum anion gap | reference range