A Case of Central Nervous System Toxicity Associated with Cyclosporine

Lee, Do-Yoon; NamGoong, Mee-Kyung; Kim, Hwang-Min; Lim, Baek-Keun

J Korean Soc Pediatr Nephrol > Volume 1(2); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(2): 179-182.

Cyclosporine에 의한 중추신경계 독성 1례

이도윤, 남궁미경, 김황민, 임백근

¹연세대학교 원주의과대학 소아과학교실
²연세대학교 원주의과대학 소아과학교실
³연세대학교 원주의과대학 소아과학교실
⁴연세대학교 원주의과대학 소아과학교실

A Case of Central Nervous System Toxicity Associated with Cyclosporine

Do-Yoon Lee, Mee-Kyung NamGoong, Hwang-Min Kim, Baek-Keun Lim

¹Department of Pediatrics, Yonsei University, Wonju College of Medicine
²Department of Pediatrics, Yonsei University, Wonju College of Medicine
³Department of Pediatrics, Yonsei University, Wonju College of Medicine
⁴Department of Pediatrics, Yonsei University, Wonju College of Medicine

ABSTRACT

Cyclosporine is an immunosuppressant usually used to prevent renal transplantation rejection. Nephrotoxicity and hypertension are considered as the most frequent side effects of cyclosporine treatment. The neurotoxic effects of cyclosporine such as agitation, anxiety, delirium, depression and psychosis have recently been found. Methylprednisolone may increase as well plasma concentration of cyclosporine, which leads to side effects. Here we report a Henoch-Schönlein nephritis patient treated with cyclosporine and methylprednisolone who has experienced psychosis including visual and auditory hallucination and convulsion.

Key words: Cyclosporine side effects | Central nervous system toxicity | Henoch-Schönlein nephritis