Various Renal Manifestations in Children with Tuberous Sclerosis Complex

Lim, Ja Hyun; Park, Moon Sung; Pai, Ki Soo; Kim, Sung Hwan; Shin, Jae Il; Park, Se Jin

doi:2014.18.2.132

Child Kidney Dis > Volume 18(2); 2014 > Article

Case Report

J Korean Soc Pediatr Nephrol 2014;18(2): 132-136. doi: https://doi.org/10.3339/jkspn.2014.18.2.132

Various Renal Manifestations in Children with Tuberous Sclerosis Complex

Ja Hyun Lim¹, Moon Sung Park¹, Ki Soo Pai¹, Sung Hwan Kim¹, Jae Il Shin², Se Jin Park³

¹Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea
²Department of Pediatrics, Yonsei University College of Medicine, Severance Children’s Hospital, Seoul, Korea
³Department of Pediatrics, Ajou University School of Medicine, Daewoo General Hospital, Geoje, Korea

Corresponding Author: Se Jin Park ,Tel: +82-55-680-8148, Fax: +82-55-680-8412, Email: fli018@hanmail.net

Received: September 25, 2014; Accepted: October 20, 2014.

ABSTRACT

Tuberous sclerosis complex (TSC) is a genetic disorder that affects multiple organ systems and causes tumors. It is important that physicians are aware of the manifestations of TSC, and that they follow the recommendations for screening and evaluation. Several types of renal abnormalities may develop in individuals with TSC. Individuals with TSC may require ongoing treatment that can be adapted for each arising manifestation of renal disease. Herein, we report 4 patients with TSC who presented with a range of different renal manifestations, including angiomyolipoma, renal cell carcinoma, renal infarction, renal cyst, and nephrolithiasis.