| Correlation between Serum Cystatin C Levels and Clinical Parameters in Children with Urinary Tract Infections |
| Ji Hyun Sim, Hyung Eun Yim, Kee Hwan Yoo |
| Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea |
Corresponding Author:
Hyung Eun Yim ,Tel: +82-31-412-5096, Fax: +82-031-405-8591, Email: he-yim@hanmail.net
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Received: September 11, 2014; Accepted: September 26, 2014. |
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| ABSTRACT |
Purpose: We aimed to investigate the correlation between serum cystatin C and clinical manifestations in pediatric patients with urinary tract infections (UTIs).
Methods: We studied 137 patients admitted with UTIs from June 2012 to May 2014. Depending on the presence of renal cortical defects on 99m Tc-dimercaptosuccinic acid scintigraphy, we classified patients into non-renal and renal defect groups. Laboratory and clinical parameters were analyzed, including the levels of serum cystatin C. The correlation between cystatin C and other variables was assessed.
Results : Serum cystatin C levels did not differ between the non-renal and renal defect groups. In both groups, serum cystatin C levels increased after 4-5 days of treatment, compared with the level at admission (P<0.001). However, mean levels were within normal ranges. The concentration of serum cystatin C positively correlated with serum creatinine and negatively correlated with age (P <0.05). In contrast, there was no correlation between serum cystatin C and other variables.
Conclusion : Serum cystatin C does not appear to be a useful biomarker for renal defects in pediatric patients with UTIs. Further studies are necessary to conclude whether serum cystatin C is helpful in predicting deterioration in renal function in pediatric patients with UTIs. |
| Key words:
Cystatin C | Urinary tract infection | Pyelonephritis |
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