Analysis of Acute Kidney Injury in Pediatric Patients with Stem Cell Transplantation

Kim, Sae-Yoon; Choi, Jung-Youn; Ha, Jeong-Ok; Park, Yong-Hoon

doi:2009.13.2.130

J Korean Soc Pediatr Nephrol > Volume 13(2); 2009 > Article

J Korean Soc Pediatr Nephrol 2009;13(2): 130-137. doi: https://doi.org/10.3339/jkspn.2009.13.2.130

소아에서 조혈모세포이식 후 급성 신질환의 분석

김세윤, 최정연, 하정옥, 박용훈

¹영남대학교 의과대학 소아과학교실
²영남대학교 의과대학 소아과학교실
³영남대학교 의과대학 소아과학교실
⁴영남대학교 의과대학 소아과학교실

Analysis of Acute Kidney Injury in Pediatric Patients with Stem Cell Transplantation

Sae-Yoon Kim, Jung-Youn Choi, Jeong-Ok Ha, Yong-Hoon Park

¹Department of Pediatrics, Yeungnam University
²Department of Pediatrics, Yeungnam University
³Department of Pediatrics, Yeungnam University
⁴Department of Pediatrics, Yeungnam University

ABSTRACT

PURPOSE: Stem cell transplantation (SCT) has gained worldwide acceptance as a treatment for hematologic disorders. This study was performed to evaluate the clinical characteristics and outcomes of acute kidney injury after SCT in children. METHODS: The records of 53 patients who were treated with SCT at the pediatric department of Yeungnam University Hospital between January, 1996 and April, 2009 were used as subjects. Their were divided into two groups ; 'Early renal insufficiency' (ERI, n=18) and 'Non-early renal insufficiency' (NERI, n=35). ERI had greater than 25% of drop in GFR after SCT. RESULTS: Total 53 patients were analyzed. In cord blood SCT (n=11), ERI was 4 (36.4%) and NERI was 7 (63.6%). In bone marrow SCT (n=16), ERI was 8 (50.0%) and NERI was 8 (50.0%). In autologous peripheral blood SCT (n=26), ERI was 6 (23.1%) and NERI was 20 (76.9%). There is no difference in both groups according to kinds of SCT. GVHD was developed in 22 patients, and there is no difference in each group. Twenty two of 53 pateints died. ERI was 12 (66.7%) and NERI was 10 (28.6%). Acute renal failure is most important cause of the deaths. CONCLUSION: Out of 53 pediatric patients who were treated with SCT, 18 patients had greater than 25% of drop in GFR. There is no difference in both groups according to kinds of SCT. GVHD was found in 22 patients and there is no relation between GVHD development and acute kidney injury.

Key words: Hematological stem cell transplantation | Renal insufficiency