A Case of Acetaminophen-induced Acute Interstitial Nephritis Presenting with Acute Renal Failure

Jeon, Hak-Su; Ha, Tae-Sun

J Korean Soc Pediatr Nephrol > Volume 10(2); 2006 > Article

J Korean Soc Pediatr Nephrol 2006;10(2): 228-232.

급성 신부전을 보인 아세트아미노펜에 의한 급성 간질성 신염 1례

전학수, 하태선

¹충북대학교 의과대학 소아과학교실
²충북대학교 의과대학 소아과학교실

A Case of Acetaminophen-induced Acute Interstitial Nephritis Presenting with Acute Renal Failure

Hak-Su Jeon, Tae-Sun Ha

¹Department of Pediatrics, College of Medicine, Chungbuk National University
²Department of Pediatrics, College of Medicine, Chungbuk National University

ABSTRACT

Acute interstital nephritis can occur by acetaminophen, but it is rarely presented as acute renal failure with azotemia. We report a case of acute interstitial nephritis induced by acetaminophen in a 14-year-old girl who developed non-oliguric acute renal failure. She has taken acetaminophen to control the persistent throat pain for the last two months. Renal biopsy revealed diffuse infiltration of mononuclear inflammatory cells admixed with eosinophils in the edematous interstitia. After the discontinuation of acetaminophen and the administration of corticosteroid, the serum creatinine level returned to normal.

Key words: Acetaminophen | Acute interstitial nephritis | Acute renal failure | Corticosteroid