J Korean Soc Pediatr Nephrol > Volume 10(1); 2006 > Article
J Korean Soc Pediatr Nephrol 2006;10(1): 1-7.
Osteopontin과 신장 발달
임형은, 유기환
1고려대학교 의과대학 소아과학교실
2고려대학교 의과대학 소아과학교실
Osteopontin and Developing Kidney
Hyung-Eun Yim, Kee-Hwan Yoo
1Department of Pediatrics, College of Medicine, Korea University
2Department of Pediatrics, College of Medicine, Korea University
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Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.
Key words: Osteopontin | UUO | Neonatal kidney
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