Expression of Tubular Intercellular Adhesion Molecule-1 (ICAM-1) as a Marker of Renal Injury in Children with IgA Nephropathy

Son, Young-Ho; Kang, Mi-Seon; Chung, Woo-Yeong

J Korean Soc Pediatr Nephrol > Volume 8(2); 2004 > Article

J Korean Soc Pediatr Nephrol 2004;8(2): 149-158.

소아 특발성 IgA 신병증에서 신 손상의 예후 인자로서 신세뇨관 ICAM-1의 발현

손영호, 강미선, 정우영

¹인제대학교 의과대학 부산백병원 소아과학교실
²인제대학교 의과대학 부산백병원 해부병리학교실
³인제대학교 의과대학 부산백병원 소아과학교실

Expression of Tubular Intercellular Adhesion Molecule-1 (ICAM-1) as a Marker of Renal Injury in Children with IgA Nephropathy

Young-Ho Son, Mi-Seon Kang, Woo-Yeong Chung

¹Departments of Pediatrics, Inje University. College of Medicine, Busan Paik Hospital,
²Departments of Pathology. Inje University. College of Medicine, Busan Paik Hospital,
³Departments of Pediatrics, Inje University. College of Medicine, Busan Paik Hospital,

ABSTRACT

PURPOSE: In order to evaluate the value of the renal expression of ICAM-1 as a marker of renal injury, we analyzed the relationship between abnormal tubular expression of ICAM-1 and histopathological features and clinical manifestations in children with IgA nephropathy (IgAN). METHODS: The clinical data from 43 patients with IgAN were analyzed retrospectively and compared to the histopathologic subclassification proposed by Haas. ICAM-1 in tubular epithelium was assessed using the LSAB(Labeled streptavidine biotin) kit on the renal biopsy specimens. RESULTS: In 43 patients with primary IgAN, 28 males and 15 females aged 12.2+/-2.2 years were studied. There were no differences of renal tubular expression of ICAM-1 between patients with gross hematuria and without gross hematuria. But renal tubular expression of ICAM-1 in patients with proteinuria was significantly higher than that of in patients without proteinuria(78.72+/-14.19% vs. 55.80+/-32.20%, P<0.05). Renal tubular expression of ICAM-1 was also associated with the severity of histopathological degree using Haas classification method. In subclass I, renal tubular expression of ICAM-1 was significantly lower than those of other subclasses. A significant correlation was found between the tubular expression of ICAM-1 and the total amount of protein in 24 hour collected urine(rs=0.47236, P<0.05). But there were no significant correlations between the renal tubular expression of ICAM-1 and interstitial cellular infiltration, tubular atrophy, and interstitial fibrosis respectively(F=0.89, P>0.05; F=0.31, P>0.05; F=0.21, P>0.05). CONCLUSION: Renal tubular expression of ICAM-1 can be a useful marker of renal injury in children with IgAN.

Key words: IgA nephropathy | Intercellular adhesion molecule-1 | Renal tubule | Predictive marker | Children