J Korean Soc Pediatr Nephrol > Volume 8(1); 2004 > Article
J Korean Soc Pediatr Nephrol 2004;8(1): 10-17.
Henoch-Schönlein Purpura 신염에서 Angiotensinogen M235T 유전자 다형성
하창우, 주희정, 박지경, 정우영
1인제대학교 의과대학 부산백병원 소아과
2인제대학교 의과대학 부산백병원 소아과
3인제대학교 의과대학 부산백병원 소아과
4인제대학교 의과대학 부산백병원 소아과
Angiotensinogen M235T Polymorphism in Children with Henoch-Schönlein Purpura Nephritis
Chang-Woo Ha, Hee-Jung Joo, Ji-Kyoung Park, Woo-Yeong Chung
1Department of Pediatrics, College of Medicine, Inje University, Busan Paik Hospital
2Department of Pediatrics, College of Medicine, Inje University, Busan Paik Hospital
3Department of Pediatrics, College of Medicine, Inje University, Busan Paik Hospital
4Department of Pediatrics, College of Medicine, Inje University, Busan Paik Hospital
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ABSTRACT
Purpose : $Henoch-Sch""{o}nlein$ purpura(HSP) nephritis has a variable range of prevalence from 25 to 50% among HSP patients and is a common cause of chronic glomerulonephritis in children. In our study, we evaluated the distribution and the association of the angioten-sinogen(AGT) M235T polymorphism with the clinical manifestations, particularly proteinuria in children with HSP with or without nephritis.
Methods : The AGT M235T polymorphism was determined in children with HSP nephritis (n=33) or HSP without nephritis(n=28) who had been diagnosed at Busan Paik hospital from January 1996 to June 2001. The M235T polymorphism of the AGT gene was determined by PCR amplification of the genomic DNA.
Results : The M235T polymorphism of AGT gene frequency was MM 75%, MT : 25%, TT : 0% in HSP and MM : 64%, MT : 36%, TT : 0% in HSP nephritis, there was no significant differences in the genotype and allele frequencies between the two groups. No significant differences in clinical manifestations at onset and last follow-up were seen between the two genotypes. When statistical analysis was done according to the presence of the M allele, the amount of 24-hour urinary protein excretion and the incidence of moderate to heavy proteinuria(>500 $mg/m^2/day$) at onset and at last follow-up were higher in the MT genotype than in those of in the MM genotype but these difference were not statistically significant.
Conclusion : We suggest a lack of association between M235T polymorphism of the AGT gene and clinical manifestations in children with HSP nephritis. However, further follow-up studies based on sufficient number of patients and long term follow up periods are necessary to confirm the role of M235T polymorphism of AGT gene in children with HSP nephritis.
Key words: HSP nephritis | AGT M235T polymorphism

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