Incidence of Vesicoureteral Reflux and Renal Scar in Asymptomatic Siblings of Patients with Primary Vesicoureteral Reflux

Yu, Je-Yun; Suck, Hyo-Chung; Song, Jun-Young; Park, Moon-Sung; Kim, Young-Soo; Pai, Ki-Soo

J Korean Soc Pediatr Nephrol > Volume 7(2); 2003 > Article

J Korean Soc Pediatr Nephrol 2003;7(2): 181-188.

선천성 방광요관역류 환아의 형제자매에서 방광요관역류와 신반흔의 유병률

유재은, 석효정, 송준영, 박문성, 김영수, 배기수

¹아주대학교 의과대학 소아과학교실
²아주대학교 의과대학 소아과학교실
³아주대학교 의과대학 소아과학교실
⁴아주대학교 의과대학 소아과학교실
⁵아주대학교 의과대학 비뇨기과학교실
⁶아주대학교 의과대학 소아과학교실

Incidence of Vesicoureteral Reflux and Renal Scar in Asymptomatic Siblings of Patients with Primary Vesicoureteral Reflux

Je-Yun Yu, Hyo-Chung Suck, Jun-Young Song, Moon-Sung Park, Young-Soo Kim, Ki-Soo Pai

¹Departments of Pediatrics, Ajou University School of Medicine
²Departments of Pediatrics, Ajou University School of Medicine
³Departments of Pediatrics, Ajou University School of Medicine
⁴Departments of Pediatrics, Ajou University School of Medicine
⁵Departments of Urology, Ajou University School of Medicine
⁶Departments of Pediatrics, Ajou University School of Medicine

ABSTRACT

Purpose : Vesicoureteral reflux(VUR) is known to be the main cause of childhood hypertension and renal failure. Knowing its familial occurrence, we determined the incidence of VUR and renal scar in asymptomatic siblings of Korean patients with primary VUR
Methods : A total of 50 siblings from 37 index patients were included. Voiding cystourethro-graphy(VCUG) and renal scintigraphy using $^{99m}Tc-DMSA$ were peformed in these siblings from June, 1994 to May, 2001, Index patients were classified into two groups according to the presence of VUR in their siblings, and the clinical factors of the index patients such as age, sex, grade of reflux and renal cortical defect were compared between the groups.
Results : Among the 50 siblings, VUR were found in 8(16%) and renal cortical defects were detected in 8(16%) siblings respectively. The incidence of renal cortical defects was 87.5%(7 out of 8) in the VUR(+) siblings. There was a case of VUR(-) cortical defect in one sibling, presumed as a scar from an old VUR. There was no relationship among age, sex, grade of reflux and renal cortical defect of the index patient to the presence of VUR in siblings.
Conclusion : This study confirmed a significant incidence of VUR(16%) and renal cortical defects(16%) in the asymptomatic siblings of patients with primary VUR in Korea. It Is resonable to recommend screening studies to the siblings of patients with VUR for the early detection and prevention of probable reflux nephropathy

Key words: Reflux nephropathy | Vesicoureteral reflux | Renal cortical defect | Siblings | Screening