J Korean Soc Pediatr Nephrol > Volume 7(1); 2003 > Article
J Korean Soc Pediatr Nephrol 2003;7(1): 9-15.
Puromycin을 투여한 백서에서 지질 변화가 신증의 진행에 미치는 영향
최광해, 정효석, 김용진, 하정희, 김흥식, 박용훈
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 소아과학교실
3영남대학교 의과대학 병리학교실
4영남대학교 의과대학 약리학교실
5계명대학교 의과대학 소아과학교실
6영남대학교 의과대학 소아과학교실
The Effect of Atorvastatin on the Development of Puromycin Aminonucleoside(PAN)-induced Nephrosis in Rats
Kwang-Hae Choi, Hyo-Seuk Chung, Yong-Jin Kim, Jeong-Hee Ha, Heung-Sik Kim, Yong-Hoon Park
1Department of Pediatrics, College of Medicine, Yeungnam University
2Department of Pediatrics, College of Medicine, Yeungnam University
3Department of Pathology, College of Medicine, Yeungnam University
4Department of Pharmacology, College of Medicine, Yeungnam University
5Deportment of Pediatrics, College of Medicine, Keimyung University
6Department of Pediatrics, College of Medicine, Yeungnam University
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Purpose : Several studies have suggested that hyperlipidemia might be a causative factor contributing to the progression of initial glomerular injury through the development of glomerulosclerosis. We examined the potential beneficial effect of atorvastatin - which blocks the rate limiting step of cholesterol synthesis by inhibiting HMG-CoA reductase - in PAN-induced nephrosis.
Materials and Methods : Glomerulosclerosis was induced in Sprague-Dawley male rats by repeated administration of PAN. Sprague-Dawley male rats were divided into 3 groups : group I(control), group II(PAN 20 mg/kg, subcutaneous injection), group III(PAN 20 mg/kg subcutaneous injection and atorvastatin 50 mg/kg/day per oral). On the 11th week, upon sacrifice of the experimental animals, blood sampling, 24-hr urine collection and nephrectomy were performed.
Results : Group III had significantly lower BUN and higher serum albumin($30.9{pm}17.2;vs.;17.3{pm}2.5;mg/dL;;2.3{pm}0.1;vs.;2.5{pm}0.2;g/dL$, P<0.05) compared with group II. In the lipid profiles, group III was associated with a reduction in total cholesterol and LDL($291{pm}173;vs.;167{pm}72;mg/dL:;57{pm}53;vs.;27{pm}12;mg/dL$, P>0.05) compared with group II. Atorvastatin administration lowered the glomerular sclerosing index significantly(26.2% vs. 13.3%, P<0.05).
Conclusion : Puromycin-induced glomerulosclerosis could be ameliorated by the reduction of hyperlipidemia with atorvastatin. This suggests that hyperlipidemia contributes to the pathogenesis of glomerulosclerosis.
Key words: Puromycin | Atorvastatin | Glomerulosclerosis | Hyperlipidemia
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