Membranous Glomerulopathy Showing Asymptomatic Isolated Microscopic Hematuria Only

Kim, Se Heui; Roh, Hyun Kyung; Lee, Young-Mock; Kim, Ji Hong; Kim, Pyung-Kil; Hong, Soon Won; Jeong, Hyun Joo

J Korean Soc Pediatr Nephrol > Volume 5(2); 2001 > Article

J Korean Soc Pediatr Nephrol 2001;5(2): 196-205.

무증상의 고립성 현미경적 혈뇨만을 나타낸 막성 사구체병증

김세희, 노현경, 이영목, 김지홍, 김병길, 홍순원, 정현주

¹연세대학교 의과대학 소아과학교실, 신장질환연구소
²연세대학교 의과대학 소아과학교실, 신장질환연구소
³연세대학교 의과대학 소아과학교실, 신장질환연구소
⁴연세대학교 의과대학 소아과학교실, 신장질환연구소
⁵연세대학교 의과대학 소아과학교실, 신장질환연구소
⁶연세대학교 의과대학 병리학교실, 신장질환연구소
⁷연세대학교 의과대학 병리학교실, 신장질환연구소

Membranous Glomerulopathy Showing Asymptomatic Isolated Microscopic Hematuria Only

Se Heui Kim, Hyun Kyung Roh, Young-Mock Lee, Ji Hong Kim, Pyung-Kil Kim, Soon Won Hong, Hyun Joo Jeong

¹Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine
²Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine
³Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine
⁴Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine
⁵Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine
⁶Departments of Pathology, The Institute of Kidney Disease, Yonsei University, College of Medicine
⁷Departments of Pathology, The Institute of Kidney Disease, Yonsei University, College of Medicine

ABSTRACT

Purpose : Membranous glomerulopathy is a glomerular disease characterized by the presence of subepithelial immune deposits with thickening of the capillary wall of the glomerulus without inflammatory change. The pathogenesis of membranous glomerulopathy is still unknown. Its incidence is higher in males, and it is rarely found in infants and adolescents. Among the clinical manifestations proteinuria is most common, while edema and hematuria are present. According to reports from other countries, among few patients diagnosed with membranous glomerulopathy by renal biopsy, show isolated microscopic hematuria without the clinical manifestations. Little research in this area has been performed in Korea, and so we conducted retrograde studies on membranous glomerulopathy associated with isolated microscopic hematuria.
Materials and Methods : We analyzed retrogradely 109 cases of asymptomatic isolated microscopic hematuria that were diagnosed as membranous glomerulopathy by renal biopsy at Yonsei University Severance hospital from January, 1992 to July, 2001.
Results : In 87 of the 109 cases patients were over 15 years old while in 22 cases patients were under 15 at the time of dignosis. Only three patients showed isolated microscopic hematuria without the clinical manifestations and abnormal laboratory findings and they were all male patients under 15 years old.
Conclusion : Few cases of the membranous glomerulopathy show only asymptomatic isolated microscopic hematuria However, since membranous glomerulopathy can be found in patients who present with asymptomatic isolated microscopic hematuria only, if adequate indication for renal biopsy is present, we conclude that renal biopsy must be aggresively pursued in order to find the underlying disease. (J Korean Soc Pediatr Nephrol 2001 ; 5 : 196-205)

Key words: Membranous glomerulopathy asymptomatic isolated microscopic hematuria