J Korean Soc Pediatr Nephrol > Volume 17(1); 2013 > Article
J Korean Soc Pediatr Nephrol 2013;17(1): 6-12. doi: https://doi.org/10.3339/jkspn.2013.17.1.6
혈전성 미세혈관병증의 병리
부산대학교 양산병원 병리과
Pathology of Thrombotic Microangiopathy
Mee Young Sol
Department of Pathology, Pusan National Universtiy Yangsan Hospital, Kyoungsangnam-do, Korea
Corresponding Author: Mee Young Sol ,Tel: 051-510-8051, Fax: 051-510-8140, Email: mysol@pusan.ac.kr
Received: March 12, 2013;  Accepted: March 26, 2013.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons. org/licenses/bync/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP. Renal biopsy finding of TMA represents kidney involvement of HUS/TTP as well as other diseases such as malignant hypertension, drug toxicity, eclampsia, pre-eclampsia, and several systemic infections. Autoimmune diseases and transplant kidney sometime also have TMA. It is needed to consider a complete autoimmune work-up of patients presenting with TMA including tests for ANA, ANCA, and ADAMTS13 inhibitory antibodies, because there are several reports of association with TMA in patients of SLE, anti-phospholipid syndrome, and ANCA-associated vasculitis.
Key words: Thrombotic microangiopathy | Renal biopsy
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