J Korean Soc Pediatr Nephrol > Volume 5(1); 2001 > Article
J Korean Soc Pediatr Nephrol 2001;5(1): 36-42.
방광 요관 역류 환아의 가족 선별 검사에 관한 연구
강희, 김형진, 유기환, 홍영숙, 이주원, 김순겸
1고려대학교 의과대학 소아과학 교실
2고려대학교 의과대학 소아과학 교실
3고려대학교 의과대학 소아과학 교실
4고려대학교 의과대학 소아과학교실
5고려대학교 의과대학 소아과학교실
6고려대학교 의과대학 소아과학교실
A Family Screening of Patients with Vesicoureteral Reflux
Hee Kang, Hyung Jin Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
1Department of Pediatrics, Korea University
2Department of Pediatrics, Korea University
3Department of Pediatrics, Korea University
4Department of Pediatrics, Korea University
5Department of Pediatrics, Korea University
6Department of Pediatrics, Korea University
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Purpose : Vesicoureteral reflux is the most commonly inherited disease detected in children with urinary tract infection. The incidence of vesicoureteral reflux among siblings of children with known vesicoureteral reflux is 8$%$ to 45$%$ according to different authors. Family screening of a patient with vesicoureteral reflux is important in order to prevent reflux nephropathy. The purpose of this study is to determine the incidence of vesicoureteral reflux in asymptomatic family of children with vesicoureteral reflux and the factors which influence the family history.
Methods : The study group consisted of 27 families of patients with vesicoureteral reflux. The total number in the group were 79 persons. BUN, Cr, urineanalysis, voidingcystourethrography(VCUG) and 99mTc -dimercaptosuccinic acid(DMSA) renal scan were performed oil tile siblings. As for tile parents the same tests were performed except the VCUG.
Results : The abnormality was detected in 7 of 27 families(25.9$%$). Vesicoureteral reflux was detected in 5 of 20 siblings and renal scar ns detected in 3 of 32 parents. In children with vesicoureteral reflux, renal scar was detected in 24 of 32 children. Between the group with the abnormality in its family(Group A) and the group without the abnormality in its family(Group B), There was no difference of creatinine clearance between two groups. More renal scars were detected in group A according to the DMSA(A:100$%$, B:75$%$. t-test P<0.05). There was no difference of grade of VCUG between two groups. There was no difference between one site and both sites in two groups. In tile case of tile siblings with vesicoureteral reflux, there was high incidence of renal scar in a patient with vesicoureteral reflux according to the DMSA.
Conclusion : It is important to screen vesicoureteral reflux and renal scar in case of urinary tract infection to prevent reflux nephropathy. This study implies that it is necessary to screen the family of a patient with vesicoureteral reflux especially with renal scar. (J, Korean Soc Pediatr Nephrol 5 : 36- 42, 2001)
Key words: Renal scar | Reflux nephropathy | Urinary tract infection

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