Significance of Random Urine β2-Microglobulin as a Marker for Vesico-ureteral Reflux in Children with Urinary Tract Infection

Kim, Ji-Hong; Kim, Pyung-Kil

J Korean Soc Pediatr Nephrol > Volume 3(1); 1999 > Article

J Korean Soc Pediatr Nephrol 1999;3(1): 72-79.

요로감염 환자에서 방광요관역류의 지표로서 무작위 추출뇨중 β2-microglobulin의 의의

김지홍, 김병길

¹연세대학교 의과대학 소아과학교실 및 신장질환연구소
²연세대학교 의과대학 소아과학교실 및 신장질환연구소

Significance of Random Urine β2-Microglobulin as a Marker for Vesico-ureteral Reflux in Children with Urinary Tract Infection

Ji-Hong Kim, Pyung-Kil Kim

¹Department of Pediatrics and Institute of Kidney Disease, Yonsei University, College of Medicine
²Department of Pediatrics and Institute of Kidney Disease, Yonsei University, College of Medicine

ABSTRACT

Renal scarring associated with vesico-ureteral reflux(VUR) is one of the major causes of end stage renal failure and renal hypertension in children. Urinary ${beta}_2$-microglobulin(MG) has been suggested as a potential marker for presence of renal tubular damage. This study was designed to evaluate the significance of random urine ${beta}_2$-MG as a predictor of presence of vesico-ureteral reflux in children with urinary tract infection(UTI). 57 children with urinary tract infection were studied. Patients were devided into two groups; 35($78.9%$) children have UTI without VUR and 12($21.1%$) children have UTI and VUR. Beta2-MG and creatinine in random urine sample was measured to decide the excretion ratio(${beta}_2$-MG/creatinine). Among the 57 children with UTI, 44 children were confirmed by urine culture study and 13 children suspected by compatible clinical feature. Random urine ${beta}_2$-MG of VUR group ($2.2{pm}5.91$ mg/L) were significantly higher than that of simple UTI group($0.19{pm}0.16mg/L$)(P=0.03). The ${beta}_2$-MG/creatinine ratio of VUR group($32.41{pm}25.7$) were significantly higher than that of simple UTI group($3.93{pm}3.44$)(P=0.007). In conclusion, random urine ${beta}_2$-MG and excretion ratio deserved early predictor of presence of VUR in children with UTI. And this method was more simple and inexpensive than the method of measuring ${beta}_2$-MG with 24 hour urine collection, so might be a useful screening test for VUR in children with UTI.

Key words: Urinary tract infection | Vesico-ureteral reflux