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Journal of the Korean Society of Pediatric Nephrology 1998;2(1): 20-25.
미세변화형 신증에서 cyclosporine A 투여 후 혈액 및 요중 endothelin-1치의 변화
김제우, 김지홍, 이진성, 김병길, 김현숙
1연세대학교 의과대학 소아과학교실 및 신장질환연구소
2연세대학교 의과대학 소아과학교실 및 신장질환연구소
3연세대학교 의과대학 소아과학교실 및 신장질환연구소
4연세대학교 의과대학 소아과학교실 및 신장질환연구소
5연세대학교 의과대학 임상병리학교실 및 신장질환연구소
Effect of Cyclosporine A on Plasma and Urine Levels of Endothelin-1 in Steroid Dependent Minimal Change Nephrotic Syndrome
Je-Woo Kim, Ji-Hong Kim, Jin-Sung Lee, Pyung-Kil Kim, Hyeon-Suk Kim
1Departments of Pediatrics, College of Medicine, Institute of Kidney Disease, Yonsei University
2Departments of Pediatrics, College of Medicine, Institute of Kidney Disease, Yonsei University
3Departments of Pediatrics, College of Medicine, Institute of Kidney Disease, Yonsei University
4Departments of Pediatrics, College of Medicine, Institute of Kidney Disease, Yonsei University
5Departments of Clinical Pathology, College of Medicine, Institute of Kidney Disease, Yonsei University
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ABSTRACT
Purpose : It has been reported that endothelin-1 can be associated with the development of cyclosporine A nephrotoxicity. Levels of endothelin-1 was assayed to determine the effect of cyclosporine A on the plasma and urine levels of this peptide. Method : Nine patients who were less than 15 years of age and were also diagnosed as steroid dependent minimal change nephrotic syndrome were included in this study. Assay of endothelin-1 was done before and 3 months after cyclosporine A treatment. The mean age of the patients was $8.3{pm}4.6$ years. Result : There was no significant differences in the plasma levels of endothelin-1 before and after 3 months of cyclosporine A treatment ($3.22{pm}0.39$ pg/mL vs. $3.84{pm}1.52$ pg/mL, P=0.64). Also there was no changes in the urine levels of endothelin-1 ($21.8{pm}5.8$ pg/mL vs. $20.3{pm}3.1$ pg/mL, P=0.30).
Conclusion : No significant changes of endothelin-1 levels were found with 3 months of cyclosporine A treatment. Further studies with longer durations will help clarifying the effect.
Key words: Cyclosporine A | Nephrotoxicity | Endothelin-1
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