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Journal of the Korean Society of Pediatric Nephrology 1997;1(2): 170-175.
혈변을 동반한 용혈성 요독 증후군 5례
김정심, 박은정, 정소희, 고시환, 엄미령, 박문수, 이흥재, 진동규
1성균관의대 소아과교실
2성균관의대 소아과교실
3성균관의대 소아과교실
4성균관의대 소아과교실
5성균관의대 소아과교실
6성균관의대 소아과교실
7성균관의대 소아과교실
8성균관의대 소아과교실
Hemolytic-uremic Syndyome Associated with Bloody Diarrhea
Jung-Sim Kim, Eun-Jung Park, So-Hee Chung, See-Hwan Ko, Mee-Ryung Uhm, Moon-Su Park, Heung-Jea Lee, Dong-Kyu Jin
1Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
2Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
3Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
4Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
5Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
6Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
7Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
8Department of Pediatrics, Sung Kyun Kwan University, College of Medicine
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ABSTRACT
Purpose : Hemolytic uremic syndrome(HUS), known as a most common cause of childhood renal failure in western countries, has been a relatively rare disease in Korea. Although the reported cases were not related to any specific cause in Korea, there was an outbreak of HUS with bloody diarrhea in Japan last year. We report here that we experienced the several typical HUS last year. Patients : From Jan.1996 to Dec. 1996, five patients were diagnosed as HUS at Samsung Seoul Medical Center, Dept. Pediatrics.
Results : 1) The age of onset was below 3 years in 3 cases and above 9 years in 2 cases. 2) All the cases happened between summer and autumn. Three patients had domestic travel and 4 patients drank well or spring water before the symptoms. 3) The clinical manifestation was generalized edema, oliguria, anuria and hematuria. The bloody diarrhea were present in 5 cases and 1 patient had operation with the impression of appendicitis. 4) There was no bacteria which was isolated from the blood or stool samples. 5) Renal biopsies were performed in 2 cases, because of protracted clinical course. One showed microthrombotic angiopathy and the other cortical necrosis with necrotizing glomeruli. 6) Complete recovery was the outcome in 4 cases and one case progressed to chronic renal failure.
Conclusion : In conclusion, typical HUS associated with bloody diarrhea, epidemic and good prognosis can be found in Korea and careful surveillance of the pre-clinical cases will be necessary.
Key words: Hemolytic uremic syndrome | Bloody diarrhea | Renal failure
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