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Journal of the Korean Society of Pediatric Nephrology 1997;1(2): 123-129.
스테로이드 저항성 신증후군 환아에서의 Methylprednisolone 충격 요법의 치료 효과
이창연, 하일수, 정해일, 최용
1고신대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
The Effect of Methylprednisolone Pulse Therapy against Steroid Resistant Nephrotic Syndrome in Children
Chang-Youn Lee, Il-Soo Ha, Hae-Il Cheong, Yong Choi
1Department of Pediatrics, Kosin Medical Center, School of Medicine
2Department of Pediatrics, Seoul National University, College of Medicine
3Department of Pediatrics, Seoul National University, College of Medicine
4Department of Pediatrics, Seoul National University, College of Medicine
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ABSTRACT
Purpose : The Childhood Steroid Resistant Nephrotic Syndrome (SRNS) has a poor prognosis and there has been no effective therapy against SRNS of children. In 1990, Mendoza have reported that methylprednisolone pulse therapy was effective against SRNS of children. But in 1992, Waldo have reported that methylprednisolone pulse therapy was not as effective as in the report of Mendoza. So, retrospectively, we have studied 20 korean children with SRNS to evaluate the effect of methylprednisolone pulse therapy,
Methods : Mothylprednisolone pulse therapy were given to 20 korean children with SRNS who admitted to Seoul National University Hospital from 1990 to 1995 and follow up was done
Results : 1) During methylprednisolone pulse therapy, remission of nephrotic syndrome was induced in 45% of patients. 2) during follow up after the end of methylprednisolone pulse therapy, remission of nephrotic syndrome was maintained in 45% of patients. 3) 25% of patients has progressed to chronic renal failure.
Conclusion : We think that the methylprednisolone pulse therapy is a effective therapy against SRNS of children with the 45%, remission rate of of SRNS in Korean Children
Key words: methylprednisolone pulse therapy | SRNS
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