Clinicopathological Analysis of Glomerulonephritis in Children

Park, Gwang-Yong; Yoon, Hye-Kyoung; Chung, Woo-Yeong

J Korean Soc Pediatr Nephrol > Volume 1(1); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(1): 4-12.

소아 사구체신염의 임상 및 병리학적 분석

박광용, 윤혜경, 정우영

¹인제의대 부산백병원 소아과학교실
²인제의대 부산백병원 병리학교실
³인제의대 부산백병원 소아과학교실

Clinicopathological Analysis of Glomerulonephritis in Children

Gwang-Yong Park, Hye-Kyoung Yoon, Woo-Yeong Chung

¹Department of Pediatrics, Inje University, College of Medicine, Pusan Paik Hospital
²Department of Pathology, Inje University, College of Medicine, Pusan Paik Hospital
³Department of Pediatrics, Inje University, College of Medicine, Pusan Paik Hospital

ABSTRACT

Purpose: To evaluate the prevalence and clinical manifestations of various glomerulonephritis (GN) in children, a clinicopathological anlysis of 310 biopsied cases were performed.
Method : We conducted retrospective study with review of histopathologic findings and clinical manifestations of the 310 cases diagnosed as glomerulonephritis by percutaneous renal biopsy which were done between January 1986 and December 1996 at department of pediatrics, Pusan Paik hospital.
Results : 1) Male to female ratio was 1.54:1 and the range of age was from 13 months to 15 years 10 months. 2) Among these, 217 (70.0%) patients were belong to primary GN and 93 (30.0%) patients were belong to secondary GN. As a whole, the most common pathologic diagnosis was minimal change lesion (MC, 32.6%), which was followed by IgA nephropathy (IgAN, 15.8%), $Henoch-Sch""{o}nlein$ purpura nephritis (HSPN, 13.5%), Poststreptococcal glomerulonephritis (PSAGN, 8.1%). 3) Clinical manifestations of patients were asymptomatic urinary abnormality (43.2%), nephrotic syndrome (41.0%), acute glomerulonephritis (14.2%), chronic glomerulonephritis (1.0%), rapidly progressive glomerulonephritis (0.6%). 4) In primary GN, the most common pathologic diagnosis was MC (46.5%), IgAN (22.6%), thin glomerular basement membrane (GBM) disease (7.8%), membranoproliferative glomerulonephritis (MPGN, 5.5%), mesangial proliferative glomerulonephritis (MesPGN,4.6%), focal segmental glomerulosclerosis (FSGS, 4.6%), membranous nephropathy (MN, 0.9%), sclerosing glomerulonephritis (SCGN, 0.9%), crescentic glomerulonephritis (CreGN, 0.5%) and non-specific glomerulonephritis (NonspGN, 6.0%). 5) Major causes of secondary GN were HSPN (45.2%), PSAGN (26.9%), hepatitis B associated glomerulonephritis (HBGN, 17.2%), lupus nephritis (LN, 6.5%), Alport syndrome (2.2%), hemolytic uremic syndrome (1.0%), fibrillary glomerulonephritis (1.0%) in descending order.
Conclusions : There are some differences of the results of clinicopathological stuidies of glomerulonephritis in children because of its different indications of renal biopsy, pathologic classification of renal disease and methods of analysis among investigators. In order to establish more reliable data of incidence and classification of childhood glomerulonephritis in Korea, multicenter cooperative study were necessary.>

Key words: Clinicopathological analysis | Glomerulonephritis | Reanl biopsy | Children