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Journal of the Korean Society of Pediatric Nephrology 2012;16(2): 138-141. doi: https://doi.org/10.3339/jkspn.2012.16.2.138
신증후군 환아에서 Rituximab 사용 후 발생한 기쿠치병 1례
이지원, 장혜진, 이상택, 강희경, 하일수, 정해일
1서울대학교 어린이병원 소아청소년과
2서울대학교 어린이병원 소아청소년과
3서울대학교 어린이병원 소아청소년과
4서울대학교 어린이병원 소아청소년과
5서울대학교 어린이병원 소아청소년과
6서울대학교 어린이병원 소아청소년과
Kikuchi-Fujimoto Disease, A Possible Complication of Rituximab Treatment
Jiwon Lee, Hye Jin Chang, Sang Taek Lee, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong
1Department of Pediatrics, Seoul National University Children's Hospital
2Department of Pediatrics, Seoul National University Children's Hospital
3Department of Pediatrics, Seoul National University Children's Hospital
4Department of Pediatrics, Seoul National University Children's Hospital
5Department of Pediatrics, Seoul National University Children's Hospital
6Department of Pediatrics, Seoul National University Children's Hospital
Received: August 31, 2012;  Revised: September 7, 2012.  Accepted: September 19, 2012.
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ABSTRACT
Rituximab, a chimeric anti-CD20 IgG1 monoclonal antibody, has been used as a rescue therapy for steroid-dependent or refractory nephrotic syndrome. However, the adverse effects of rituximab are yet to be investigated. We report a case of a 9-year-old boy with steroid-dependent nephrotic syndrome who developed Kikuchi-Fujimoto disease after several cycles of rituximab therapy. Kikuchi-Fujimoto disease is a benign, self-limited necrotizing histiocytic lymphadenitis of unknown etiology. In the present case, Kikuchi-Fujimoto disease developed when the peripheral blood B-cell count of the patient was at nadir, and the lesion regressed slowly but spontaneously after recovery of the B-cell count. To our knowledge, although the pathologic diagnosis of Kikuchi-Fujimoto disease was unavailable, this is the first report of Kikuchi-Fujimoto disease with clinical diagnosis as a possible adverse effect of rituximab.
Key words: B-cell | Kikuchi-Fujimoto disease | Nephrotic syndrome | Rituximab
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