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Journal of the Korean Society of Pediatric Nephrology 2011;15(2): 146-153. doi: https://doi.org/10.3339/jkspn.2011.15.2.146
일차성 단일증상성 야뇨증 환아에서 소변내로의 요칼슘배설에 대한 연구
정우영, 조민현, 박용훈, 대한 소아배뇨장애야뇨증학회
1인제의대 부산백병원 소아청소년과
2경북의대 소아청소년과
3영남의대 소아청소년과
4대한 소아배뇨장애야뇨증학회
Urinary Calcium Excretion in Children with Primary Monosymptomatic Nocturnal Enuresis
Woo-Yeong Chung, Min-Hyun Cho, Yong-Hoon Park,
1Department of Pediatrics, Busan Paik Hospital, College of Medicine, Inje University
2Department of Pediatrics, Kyungpook National University School of Medicine
3Department of Pediatrics, Yeung Nam University, College of Medicine
4The Korean Children's Continence and Enuresis Society
Received: July 27, 2011;  Accepted: August 31, 2011.
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Purpose : Hypercalciuria has been suggested to be involved in the pathogenesis of nocturnal enuresis associated with polyuria. We have measured the amount of calcium excretion in the urine from children with monosymptomatic nocturnal enuresis and studied the association with enuresis.
Methods : Thirty-six children (20 males and 16 females, age 5 to 15.6 years) presenting with monosymptomatic nocturnal enuresis were recruited for this study.
Results : Among 36 patients, 6 patients had hypercalciuria, providing a 16.7% frequency. The mean Ca/Cr ratio of hypercalciuria group showed $0.23{pm}0.10$ on daytime, and $0.33{pm}0.10$ on nighttime showing higher values in nighttime, but it was not statistically significant. Average 24 hour calcium excretion was 8.95 mg/kg. Night/day time urine volume ratio in hypercalciuria group was $0.87{pm}0.20$, and that in normocalciuria group was $0.81{pm}0.33$, also showing no difference. Daytime Ca/Cr ratio and nighttime Ca/Cr ratio from all enuresis patients showed a significant correlation (P=0.0001). However, Ca/Cr ratio between daytime and nighttime urine volume had no significant correlation, respectively (daytime P=0.08; nighttime P=0.07). Also, daytime and nighttime Na concentration, urea concentration, and osmolality also had no significant correlation with urine Ca/Cr ratio, respectively.
Conclusion : Hypercalciuria shown in some of enuresis patients is not directly caused by primary monosymptomatic nocturnal enuresis.
Key words: Children | Primary monosymptomatic nocturnal enuresis | Hypercalciuria
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