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Journal of the Korean Society of Pediatric Nephrology 2011;15(2): 125-137. doi: https://doi.org/10.3339/jkspn.2011.15.2.125
폐쇄성 요로병증에서 $17{beta}$-estradiol에 의한 신섬유화 감소 효과에 대한 연구
조민현, 장희성, 정경진, 박권무
1경북대학교 의학전문대학원 소아과학교실
2경북대학교 의학전문대학원 해부학교실
3경북대학교 의학전문대학원 해부학교실
4경북대학교 의학전문대학원 해부학교실
$17{beta}$-estradiol Attenuates Renal Fibrosis in Mice with Obstructive Uropathy
Min-Hyun Cho, Hee-Seong Jang, Kyung-Jin Jung, Kwon-Moo Park
1Department of Pediatrics, Kyungpook National University School of Medicine
2Department of Anatomy, Kyungpook National University School of Medicine
3Department of Anatomy, Kyungpook National University School of Medicine
4Department of Anatomy, Kyungpook National University School of Medicine
Received: April 12, 2011;  Accepted: June 15, 2011.
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ABSTRACT
Purpose : Men are generally more prone to chronic renal disease and progression to end stage renal disease than women. The purpose of this study is to prove the effect of gender and sex hormone on renal fibrosis in mice with unilateral ureteral obstruction (UUO) and to elucidate the specific underlying mechanisms.
Methods :We compared the expression of ${alpha}$-smooth muscle actin (${alpha}$-SMA) in female and male mice with complete UUO (day 7). After this, we estimated the changes of renal fibrosis in the female mice with oophorectomy and in the female mice with oophorectomy and replacement of $17{beta}$-estradiol, respectively.
Results : The level of ${alpha}$-SMA in the female kidney with UUO was significantly lower than that in the male kidney with UUO. oophorectomy and replacement of $17{beta}$-estradiol did not change the expression of angiotensin II type 1 (AT1) receptor in the female kidney with UUO, whereas the expression of angiotensin II type 2 (AT2) receptor was significantly more elevated in the intact female (IF) and the oophorectomized female with estrogen (OF+E) than that in the oophorectomized female (OF). The expressions of inducible nitric oxide synthase (iNOS) in the IF and OF+E mice were significantly more elevated than that in the OF mice, which was similar to the expression of AT2 receptor.
Conclusion : The female gender is associated with resistance to renal fibrosis in obstructive uropathy and this gender difference may originate from the existence of $17{beta}$-estradiol, which has an anti-fibrotic effect via upregulation of the AT2 receptor and iNOS.
Key words: Renal fibrosis | Ureteral obstruction | Gender | $17{\beta}$-estradiol
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