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Journal of the Korean Society of Pediatric Nephrology 2010;14(1): 94-99. doi: https://doi.org/10.3339/jkspn.2010.14.1.94
만성 신부전으로 진행된 비만 연관 사구체병증 1례
안정희, 윤정림, 문경철, 구자욱
1인제대학교 의과대학 상계백병원 소아청소년과
2인제대학교 의과대학 상계백병원 소아청소년과
3서울대학교 의과대학 병리과학교실
4인제대학교 의과대학 상계백병원 소아청소년과
Obesity Related Glomerulopathy Progressed to Chronic Renal Failure
Jung-Hee Ahn, Jung-Rim Yoon, Kyung-Chul Moon, Ja-Wook Koo
1Department of Pediatrics, Inje University College of Medicine, Sanggye Paik Hospital
2Department of Pediatrics, Inje University College of Medicine, Sanggye Paik Hospital
3Department of Pathology, Seoul National University school of Medicine
4Department of Pediatrics, Inje University College of Medicine, Sanggye Paik Hospital
Received: March 19, 2010;  Revised: March 31, 2010.  Accepted: April 12, 2010.
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ABSTRACT
Obesity-related glomerulopathy (ORG) is a secondary form of focal and segmental glomerulosclerosis (FSGS) manifesting as proteinuria and progressive renal dysfunction that results from maladaptive glomerular response to increasing adiposity. Reports of ORG progressing to end stage renal diseases in rare in the pediatric population. We report a 9-year-old boy with obesity (body mass index $35;kg/m^2$) who was diagnosed with ORG presenting with proteinuria. He was diagnosed with obesity-related glomerulopathy based on the laboratory, urinary, and kidney biopsy finding. In spite of treatment with angiotensin- converting enzyme (ACE) inhibitor and/or, angiotensin-receptor blocking agent, the degree or amount of proteinuria increased and renal function declined continuously. His BMI did not decrease and eventually progressed to chronic renal failure. Consequently, obese patients should be monitored for proteinuria, which may be the first manifestation of FSGS, a lesion that may be associated with serious renal sequelae.
Key words: Obesity | Glomerulosclerosis | Chronic renal failure
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