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Journal of the Korean Society of Pediatric Nephrology 2010;14(1): 51-61. doi: https://doi.org/10.3339/jkspn.2010.14.1.51
소아 IgA 신병증 환자에서 임상병리 양상과 CCL-2 및 CCL-5 유전자 다형성의 연관성 연구
한원호, 서진순, 조병수
1경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소
2경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소
3경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소
Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy
Won-Ho Hahn, Jin-Soon Suh, Byoung-Soo Cho
1Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University
2Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University
3Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University
Received: March 27, 2010;  Revised: April 13, 2010.  Accepted: April 21, 2010.
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ABSTRACT
Purpose : Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory and non-inflammatory renal diseases. The present study was conducted to investigate association of polymorphisms of CCL-2 and CCL-5 genes with childhood IgA nephropathy (IgAN).
Methods : The authors analyzed six single nucleotide polymorphisms (SNPs) of CCL-2 and CCL-5 in 196 pediatric IgAN patients and in 285 healthy controls. We compared variations in SNPs between two several sets of IgAN subgroups, allocated by presence of proteinuria (>4 mg/$m^2$/hour), podocyte foot process effacement, and pathologically advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis.
Results : Genotypic data of IgAN patients and controls showed no significant SNP frequency difference in both of of CCL-2 and CCL-5. Even though two linkage disequilibrium blocks were formed, there was no significance in the haplotype analysis. In the patient subgroup analysis, no SNP of CCL-2 and CCL-5 was found to be associated with the presence of proteinuria, podocyte foot process effacement, and pathologically advanced disease markers.
Conclusion : Our data indicate that no association exists between CCL-2 and CCL-5 SNPs and childhood IgAN susceptibility, and presence of proteinuria, podocyte foot process effacement, and pathologic progression of IgAN.
Key words: CCL-2 | MCP-1 | CCL-5 | RANTES | Chemokine | Polymorphism | IgA nephropathy
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