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Journal of the Korean Society of Pediatric Nephrology 2010;14(1): 10-21. doi: https://doi.org/10.3339/jkspn.2010.14.1.10
소아의 심한 헤노흐-쇤라인 자반증의 치료
신재일, 이재승
1연세대학교 의과대학 소아과학교실 신장질환 연구소, 세브란스 어린이병원
2연세대학교 의과대학 소아과학교실 신장질환 연구소, 세브란스 어린이병원
Treatment of Severe Henoch-Schoenlein Purpura Nephritis in Children
Jae-Il Shin, Jae-Seung Lee
1The Institute of Kidney Disease, Department of Pediatrics Yonsei University College of Medicine, Severance Children's Hospital
2The Institute of Kidney Disease, Department of Pediatrics Yonsei University College of Medicine, Severance Children's Hospital
Received: March 28, 2010;  Revised: April 7, 2010.  Accepted: April 12, 2010.
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ABSTRACT
The overall prognosis of Henoch-Schoenlein purpura (HSP) is favorable, but severe nephritis has a high risk of progression to end stage renal failure. Recent studies emphasize the importance of early treatment in children with severe HSP nephritis, but the treatment of severe HSP nephritis still remains controversial due to the rarity of randomized controlled studies in this field. Nevertheless, several intensive therapies, such as intravenous high-dose methylprednisolone pulse, immunosuppressive/cytotoxic drugs, fibrinolytic therapy, anticoagulants, antiplatelet agent and plasma exchange, have been used in children with severe HSP nephritis. In this review, we focus on the treatment of severe HSP nephritis in children.
Key words: Henoch-Schoenlein purpura | Severe Henoch-Schoenlein purpura nephritis | Intensive therapy | Children
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