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Journal of the Korean Society of Pediatric Nephrology 2009;13(2): 146-152. doi: https://doi.org/10.3339/jkspn.2009.13.2.146
Henoch-$Sch{ddot{o}}nlein$ 자반증에서 항인지질 항체의 임상적 의의
박은정, 백지영, 신재일, 이재승, 김현숙
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4연세대학교 의과대학 소아과학교실
5연세대학교 의과대학 진단검사의학교실
The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-$Sch{ddot{o}}nlein$ Purpura
Eun-Jung Park, Ji-Young Baek, Jae-Il Shin, Jae-Seung Lee, Hyon-Suk Kim
1Department of Pediatrics, Yonsei University college of Medicine
2Department of Pediatrics, Yonsei University college of Medicine
3Department of Pediatrics, Yonsei University college of Medicine
4Department of Pediatrics, Yonsei University college of Medicine
5Department of Laboratory Medicine, Yonsei University college of Medicine
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ABSTRACT
Purpose : We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-$Sch{ddot{o}}nlein$ purpura (HSP).
Methods : The medical records of 62 patients (31 boys and 31 girls) aged $46.0{pm}3.1$ (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-${beta}_2$ glycoprotein I antibody.
Results : LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein ($4.3{pm}7.2$ mg/dL vs. $1.3{pm}1.8$ mg/dL, P=0.035), erythrocyte sedimentation rate ($37.5{pm}26.2$ mm/hr vs. $25.1{pm}22.6$ mm/hr, P= 0.039), IgM ($148.1{pm}48.4$ mg/dL vs. $114.9{pm}41.5$ mg/dL, P=0.024), C3 ($143.1{pm}21.9$ mg/dL vs. $129.7{pm}24.5$ mg/dL, P=0.048) and C4 levels ($30.9{pm}6.3$ mg/dL vs. $24.9{pm}7.8$ mg/dL, P=0.002) compared with LA negative group.
Conclusion : We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.
Key words: Henoch-$Sch{\ddot{o}}nlein$ purpura | Antiphospholipid antibodies | Lupus anticoagulant
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