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Journal of the Korean Society of Pediatric Nephrology 2008;12(2): 170-177. doi: https://doi.org/10.3339/jkspn.2008.12.2.170
소아 Henoch-$Sch{ddot{o}}nlein$ purpura에서 스테로이드 치료 기간에 따른 임상적 결과의 비교
이수진, 신재일, 이종국, 김기혁
1국민건강 보험공단 일산병원 소아과
2연세대학교 의과대학 소아과학교실
3인제대학교 의과대학 일산 백병원 소아과
4국민건강 보험공단 일산병원 소아과
Comparison of Clinical Outcome According to the Duration of Corticosteroid Therapy in Childhood Henoch-$Sch{ddot{o}}nlein$ Purpura: a Bicentric Study
Su-Jin Lee, Jae-Il Shin, Chong-Guk Lee, Kee-Hyuck Kim
1Department of Pediatrics, NHIC Ilsan Hospital
2Department of Pediatrics Yonsei University College of Medicine Severance Children's Hospital
3Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine
4Department of Pediatrics, NHIC Ilsan Hospital
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ABSTRACT
Purpose : The aim of this study was to evaluate whether the incidence of relapse or nephritis might be influenced by the duration of corticosteroid therapy in children with Henoch-Schonlein purpura(HSP).
Methods : We retrospectively analyzed 186 children with a diagnosis of HSP in two major hospitals in Ilsan, Korea from the years 2000 to 2003. To evaluate whether renal involvement or relapse might be influenced by the duration of corticosteroid therapy in children with HSP, one pediatric nephrologist from hospital A, maintained corticosteroid therapy for at least 2 weeks(Group A, n=94). The other from hospital B used only during the symptomatic period(Group B, n=92).
Results : There were no significant differences in age, sex, body weight, white blood cell count, hemoglobin, hematocrit, platelet count, serum protein and albumin levels between the two groups. The incidence of abdominal pain or arthralgia also did not differ between two groups. However, the duration of steroid therapy was significantly longer in Group A than in Group B and the cumulative dose of prednisolone was also higher in Group A than in Group B. The development of nephritis was more frequent in Group A.
Conclusion : The longer duration of steroid use was not associated with the decreased rate of nephritis. Therefore, corticosteroids should be used carefully in a selected group of HSP children, and be tapered rapidly after control of the acute symptoms.
Key words: Henoch-$Sch{\ddot{o}}nlein$ purpura | Corticosteroid | Duration | Nephritis | Relapse
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