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Journal of the Korean Society of Pediatric Nephrology 2008;12(1): 30-37. doi: https://doi.org/10.3339/jkspn.2008.12.1.30
소아에서의 급성 신성신부전의 임상적 고찰
권은지, 정지미, 정우영
1인제대학교 부산백병원 소아청소년과
2인제대학교 부산백병원 소아청소년과
3인제대학교 부산백병원 소아청소년과
Clinical Analysis of Acute Intrinsic Renal Failure in Neonates and Children
Eun-Ji Kwon, Ji-Mi Jung, Woo-Yeung Chung
1Inje University, College of Medicine, Department of Pediatrics, Busan Paik Hospital
2Inje University, College of Medicine, Department of Pediatrics, Busan Paik Hospital
3Inje University, College of Medicine, Department of Pediatrics, Busan Paik Hospital
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ABSTRACT
Purpose: The present study is an investigation of the progression and prognosis of acute intrinsic renal failure in neonates and children with a diagnosis of acute renal failure or other diseases on admission.
Methods: This research is based on a retrospective analysis conducted on 59 patients(male: female=2.2:1) diagnosed with acute intrinsic renal failure between January 2000 and June 2006 at Busan Paik Hospital. The clinical diagnostic criteria of acute renal failure used was serum creatinine <1.2 mg/dL, oliguria with urine output$leq$0.5 mL/kg/hr and anuria with urine output <50 mL per day.
Results : Among those placed under investigation, 7 patients were neonates, 10 patients were 2 months-2 years old, 12 patients were 3-6 years old, 21 patients were 7-12 years old and 9 patients were 13-16 years old. It took 3.1${pm}$2.8 days on average until the diagnosis was made. The urine output distribution was 21 persons for the oliguria group, and 36 persons for the non-oliguria group, and 2 persons for the anuria group. For the underlying causes, 30 persons were classified in the primary renal disease group, 14 persons in the infection group, 9 persons in the malignancy group, and 6 persons were categorized in another group. As for age distribution, the infected group was predominantly neonates, whereas the dominant age ranges for the primary renal disease and infection categories were 2 months to 2 years old. Also, the primary renal disease was dominant among older children, aged 3 and up. No difference was detected according to seasonal prevalence. However, there was a high morbidity rate among hemolytic uremic syndrome diagnosed in the summer. Peritoneal dialysis was used to treat 4 patients. It took 10.0${pm}$6.7 days until the patients improved. 18 patients died. The non-oliguria group's mortality rate was lower than other groups. There was a high mortality rate in the neonates and malignancy group.
Conclusion : Acute renal failure in childhood seems to take a better clinical course than in adulthood when there is an early diagnosis and proper treatment of underlying diseases.
Key words: Acute Renal Failure | Renal Type | Children
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