Allograft Immune Reaction of Kidney Transplantation Part 1. Mechanism of Allograft Rejection

Kang, Hee-Gyung

doi:2008.12.1.23

J Korean Soc Pediatr Nephrol > Volume 12(1); 2008 > Article

J Korean Soc Pediatr Nephrol 2008;12(1): 23-29. doi: https://doi.org/10.3339/jkspn.2008.12.1.23

신이식 후 면역반응의 이해 - 1부. 이식 거부 반응의 기전 -

강희경

서울대학교 의과대학 소아과학교실

Allograft Immune Reaction of Kidney Transplantation Part 1. Mechanism of Allograft Rejection

Hee-Gyung Kang

Department of Pediatrics, Seoul National University School of Medicine

ABSTRACT

Kidney allograft transplantation is the most effective method of renal replacement for end stage renal disease patients. Still, it is another kind of 'disease', requiring immunosuppression to keep the allograft from rejection(allograft immune reaction). Immune system of the allograft recipient recognizes the graft as a 'pathogen (foreign or danger)', and the allograft-recognizing commanderin-chief of adaptive immune system, T cell, recruits all the components of immune system for attacking the graft. Proper activation and proliferation of T cell require signals from recognizing proper epitope(processed antigen by antigen presenting cell) via T cell receptor, costimulatory stimuli, and cytokines(IL-2). Thus, most of the immunosuppressive agents suppress the process of T cell activation and proliferation.

Key words: Allograft immunity | Immune reaction | Renal allograft | Allograft tolerance