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Journal of the Korean Society of Pediatric Nephrology 2007;11(2): 239-246. doi: https://doi.org/10.3339/jkspn.2007.11.2.239
소아 만성 신질환 진행의 위험인자 분석-단일기관 연구
한경희, 이성하, 이현경, 최현진, 이범희, 조희연, 정해일, 최용, 하일수
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실
6가천의과학대학교 길병원 소아과학교실
7서울대학교 의과대학 소아과학교실
8서울대학교 의과대학 소아과학교실
9서울대학교 의과대학 소아과학교실
Risk Factors for the Progression of Pediatric Chronic Kidney Disease-A Single Center Study
Kyoung-Hee Han, Sung-Ha Lee, Hyun-Kyung Lee, Hyun-Jin Choi, Bum-Hee Lee, Hee-Yeon Cho, Hae-Il Cheong, Yong Choi, Il-Soo Ha
1Department of Pediatrics, Seoul National University College of Medicine
2Department of Pediatrics, Seoul National University College of Medicine
3Department of Pediatrics, Seoul National University College of Medicine
4Department of Pediatrics, Seoul National University College of Medicine
5Department of Pediatrics, Seoul National University College of Medicine
6Department of Pediatrics, Gachon University Gil Medical Center
7Department of Pediatrics, Seoul National University College of Medicine
8Department of Pediatrics, Seoul National University College of Medicine
9Department of Pediatrics, Seoul National University College of Medicine
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ABSTRACT
Purpose : The progressive deterioration of renal function in children can impose a serious and lifelong impact on their lives. The ultimate goal in the management of children with chronic kidney disease(CKD) is to prolong survival, to prevent complications, and to promote growth and neurodevelopment. The aim of this study is to investigate the risk factors for the decline of renal function in pediatric CKD patients.
Methods : Data from patients who met the criteria for the Kidney Disease Outcomes Quality Initiative(K/DOQI) CKD stage 2 to 4 between August 1999 and March 2007 were retrospectively analyzed. The estimated glomerular filtration rate(eGFR) was calculated by the Schwartz formula, using serum creatinine levels and height. We calculated the annual eGFR change from the difference between the baseline eGFR and the last eGFR divided by the duration(years) of the follow-up period. We analyzed the association between the annual eGFR change and factors such as age, gender, K/DOQI stage, underlying renal disease, serum calcium, and inorganic phosphorous during the follow-up period.
Results : Sixty one children(44 boys & 17 girls) were enrolled. The age at entry was $7.1{pm}4.7$ years. The annual eGFR change was $-1.2{pm}11.9 mL/min/1.73m^2/year$. Our study showed that older age(P=0.005). hypocalcemia(P=0.012), and hypenhosphatemia(P=0.002) were significantly related to more rapid decline in renal function.
Conclusion : In pediatric CKD, older age, hypocalcemia and hyperphosphatemia are related to more rapid deterioration of renal function.
Key words: Chronic kidney disease | eGFR | Age | Hypocalcemia | Hyperphosphatemia | Children
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