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Journal of the Korean Society of Pediatric Nephrology 2007;11(1): 16-23. doi: https://doi.org/10.3339/jkspn.2007.11.1.16
소아 미세변화형 신증후군에서 혈청 알부민과 IgG의 상관관계
곽가영, 김동언, 고대균, 이준성, 이경일
1가톨릭대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 소아과학교실
3가톨릭대학교 의과대학 소아과학교실
4가톨릭대학교 의과대학 소아과학교실
5가톨릭대학교 의과대학 소아과학교실
Correlation between Serum Albumin Level and IgG Level in Minimal Change Nephrotic Syndrome
Ga-Young Kwak, Dong-Un Kim, Dae-Kyun Koh, Joon-Sung Lee, Kyung-Yil Lee
1Department of Pediatrics, College of Medicine, the Catholic University of Korea
2Department of Pediatrics, College of Medicine, the Catholic University of Korea
3Department of Pediatrics, College of Medicine, the Catholic University of Korea
4Department of Pediatrics, College of Medicine, the Catholic University of Korea
5Department of Pediatrics, College of Medicine, the Catholic University of Korea
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ABSTRACT
Purpose : Hypogammaglobulinemia has been observed in nephrotic syndrome, but its pathophysiology remains unknown. We evaluated the relationship between the serum IgG and at bumin levels for children with minimal change nephrotic syndrome(MCNS).
Methods : The levels of immunoglobulin G(IgG), albumin and total cholesterol of a total of 46 children with MCNS(proteinuria $>40mg/m^2/h$, and serum albumin level <2.5g/dL were analyzed.
Results : The mean values of albumin, IgG and total cholesterol in MCNS children were $1.7{pm}0.3g/dL,;368{pm}143mg/dL;and;431{pm}78mg/dL$, respectively. There was an inverse correlation between the albumin values and the total cholesterol values(r=0.68, P=0.0001), whereas there was a direct-proportional correlation between albumin values and the IgG values(r=0.4, P=0.01).
Conclusion : The IgG level is associated with albumin level, and it may reflect the severity of urinary protein loss in MCNS. Further studies are needed to evaluate this phenomenon.
Key words: Nephrotic syndrome | Albumin | Cholesterol | Immunoglobuin G
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