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Journal of the Korean Society of Pediatric Nephrology 2004;8(2): 250-255.
월슨병 환아에서 D-penicillamine 사용 중 조기 발병한 미세변화형 신증후군 1례
김기수, 임재우, 고경옥, 김윤미, 천은정
1건양대학교 의과대학 소아과학교실
2건양대학교 의과대학 소아과학교실
3건양대학교 의과대학 소아과학교실
4건양대학교 의과대학 병리학교실
5건양대학교 의과대학 소아과학교실
Early Onset of Minimal change Nephrotic Syndrome during Treatment with D-penicillamine in a Patient with Wilson's Disease
Ki-Soo Kim, Jae-Woo Lim, Kyong-Og Ko, Yoon-Mee Kim, Eun-Jung Cheon
1Departments of Pediatrics, College of Medicine, Konyang Uniuersity
2Departments of Pediatrics, College of Medicine, Konyang Uniuersity
3Departments of Pediatrics, College of Medicine, Konyang Uniuersity
4Departments of Pathology, College of Medicine, Konyang Uniuersity
5Departments of Pediatrics, College of Medicine, Konyang Uniuersity
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Wilson's disease is an autosomal recessive disorder characterized by degenerative changes in the brain, liver, and cornea. Treatment includes D-penicillamine, trientine, and zinc sulfate. D-penicillamine has been used frequently as first line therapy for Wilson's disease. However, nephrotoxicity can occur after D-penlcillamlne treatment. Among them membranous glomerulopathy is the most common histological abnormality but minimal change lesions have also been reported. Nephrotic syndrome is a late complication of D-penicillamine treatment but very rarely can occur within 2 months after treatment of D-penicillamine. We report the early development of minimal change nephrotic syn,frome in a 3-year-old'girl with Wilson's disease 3 weeks after initiation of D-penicillamine.
Key words: Wilson's disease | D-penicillamine | Nephrotic syndrome
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