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Journal of the Korean Society of Pediatric Nephrology 2003;7(1): 30-37.
소아 $Henoch-Sch""{o}nlein$ 자반병 신염의 임상양상 및 병리소견과 임상경과
허윤정, 신재일, 박지민, 정현주, 이재승
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4연세대학교 의과대학 병리학교실
5연세대학교 의과대학 소아과학교실
Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood $Henoch-Sch""{o}nlein$ Purpura Nephritis
Yun-Jung Huh, Jae-Il Shin, Jee-Min Park, Hyeon-Joo Jeong, Jae-Seung Lee
1Department of Pediatrics, Yonsei University College of Medicine
2Department of Pediatrics, Yonsei University College of Medicine
3Department of Pediatrics, Yonsei University College of Medicine
4Department of Pathology, Yonsei University College of Medicine
5Department of Pediatrics, Yonsei University College of Medicine
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ABSTRACT
Purpose : $Henoch-Sch""{o}nlein$ purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven $Henoch-Sch""{o}nlein$ purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings.
Methods : The clinical features, initial laboratory and pathologic findings, and clinical out-come were evaluated in 60 children with biopsy-proven $Henoch-Sch""{o}nlein$ purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002.
Results : The ratio of male to female patients was 1.2:1. The interval between the onset of $Henoch-Sch""{o}nlein$ purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome In 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome.
Conclusion : Renal manifestation and pathologic findings correlated with the clinical out-come. It is necessary to evaluate the correlation between pathologic findings and treatment.
Key words: $Henoch-Sch\""{o}nlein$ purpura nephritis | Pathology | Prognosis
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