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Journal of the Korean Society of Pediatric Nephrology 2003;7(1): 16-22.
미세변화신증후군 환아에서 Tumor Necrosis Factor-${alpha}$의 혈중 및 요중 변화와 알부민 투과성에 미치는 영향
조민현, 이환석, 오현희, 정기영, 구자훈, 고철우
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 소아과학교실
3경북대학교 의과대학 소아과학교실
4경북대학교 생명의학연구소
5경북대학교 의과대학 소아과학교실
6경북대학교 의과대학 소아과학교실
Changes of Plasma and Urinary $TNF-{alpha}$ in Children with Minimal Change Nephrotic Syndrome and Its Role in Albumin Permeability
Min-Hyun Cho, Hwan-Seok Lee, Hyun-Hee Oh, Ki-Young Chung, Ja-Hoon Koo, Cheol-Woo Ko
1Department of Pediatrics, Kyungpook National University Hospital
2Department of Pediatrics, Kyungpook National University Hospital
3Department of Pediatrics, Kyungpook National University Hospital
4Department of Biomedical Research Institute, Kyungpook National University Hospital
5Department of Pediatrics, Kyungpook National University Hospital
6Department of Pediatrics, Kyungpook National University Hospital
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Purpose : Minimal Change Disease(MCD) is the most common primary nephrotic syndrome in children. Some suggested that tumor necrosis factor-${alpha}$ ($TNF-{alpha}$) are involved in the pathogenesis of MCD. This study was done to see the changes of plasma and urinary $TNF-{alpha}$, and their effects on the permeability of glomerular basement membrane.
Methods : Study patients consisted of 19 biopsy-proven MCD children aged 2-15 years old. Both plasma and urinary $TNF-{alpha}$ were measured. Employing the Millicell system, $TNF-{alpha}$ were screened for the permeability factors.
Results : Urinary $TNF-{alpha}$ during relapse was significantly increased(P<0.01). No significant change was seen in the plasma $TNF-{alpha}$ during relapse when compared to those in remission and the healthy controls. Furthermore, in the in vitro Millicell system, $TNF-{alpha}$ did not produce a significant change in albumin permeability.
Conclusion : Therefore, it seems that $TNF-{alpha}$ may not play a disease-specific role in the pathogenesis of MCD.
Key words: $TNF-{\alpha}$ | Minimal change nephrotic syndrome | Albumin permeability
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