| Home | E-Submission | Sitemap | Contact Us
Journal of the Korean Society of Pediatric Nephrology 2002;6(1): 85-91.
일측성 요로폐쇄에 의한 실험적 신 간질 섬유화에서 Phosphodiesterase(PDE) 억제제의 항 섬유화 작용
하일수, 엄은영, 강희경, 한혜원, 박혜원, 정해일, 최용
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실
6서울대학교 의과대학 소아과학교실
7서울대학교 의과대학 소아과학교실
Antifibrotic Effects of Phosphodiesterase (PDE) Inhibitor in Experimental Interstitial Fibrosis induced by Unilateral Ureteral Obstruction.
Il Soo Ha, Eun Young Um, Hee-Gyung Kang, Hye Won Hahn, Hye Won Park, Hae Il Cheong, Yong Choi
1Department of Pediatrics, Seoul National University College of Medicine
2Department of Pediatrics, Seoul National University College of Medicine
3Department of Pediatrics, Seoul National University College of Medicine
4Department of Pediatrics, Seoul National University College of Medicine
5Department of Pediatrics, Seoul National University College of Medicine
6Department of Pediatrics, Seoul National University College of Medicine
7Department of Pediatrics, Seoul National University College of Medicine
Share :  
ABSTRACT
Purpose: Phosphodiesterase (PDE) inhibitor increases the cellular content of cAMP, and cAMP suppresses connective tissue growth factor (CTGF) expression induced by TGF-${beta}1$. Therefore, we investigated whether PDE inhibitor suppresses renal fibrosis without suppression of TGF-${beta}1$.
Materials and Methods : Renal interstitial fibrosis was produced by ligation of left ureter in Sprague-Dawley rats. Cilostazol, a selective PDE3 inhibitor, and dipyridamole, a hybrid PDE5, PDE6, and PDE8 inhibitor, were provided in drinking water for 7 days. In addition to the Masson-trichrome score of renal tissue, the concentration of fibronectin and TGF-${beta}1$ in renal tissue- conditioned media was measured by ELISA.
Results : Masson- trichrome score and fibronectin concentration were significantly lower in cilostazol-treated group compared to the control group (P<0.05). Though dipyridamole treatment seemed to suppress the Masson- trichrome score and fibronectin concentration too, the decrements were not statistically significant. There was no difference in TGF-${beta}1$ concentration among the groups.
Conclusion : A selective PDE3 inhibitor cilostazol suppresses renal fibrosis without alteration of TGF-${beta}1$ expression. (J Korean Soc Pediatr Nephrol 2002 ;6 : 85-91)
Key words: Phosphodiesterase (PDE) inhibitor | Cilostazol | Dipyridamole | Interstitial fibrosis | Unilateral ureteral obstruction | Rat
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplement  Supplement
  E-Mail
Share:      
METRICS
461
View
2
Download
Editorial Office
50 Yonsei-Ro, Seodaemun-Gu, Department of Pediatrics, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea
TEL : +82-2-2228-2050   FAX : +82-2-393-9118   E-mail : chikd.editor@gmail.com

Copyright© Korean Society of Pediatric Nephrology. All rights reserved.                powerd by m2community
About |  Browse Articles |  Current Issue |  For Authors and Reviewers