| Home | E-Submission | Sitemap | Contact Us |  
Journal of the Korean Society of Pediatric Nephrology 2001;5(2): 100-108.
소아 미세변화 신증후군에서 폐색전증에 대한 연구
성승준, 홍기웅, 김은령, 김일수, 조병수
1성애병원 소아과
2성애병원 소아과
3성애병원 소아과
4성애병원 소아과
5경희의대 소아과
Pulmonary Embolism In Childhood Minimal Change Nephrotic Syndrome
Seung-Joon Sung, Ki-Woong Hong, Eun-Ryoung Kim, Il-Soo Kim, Byung-Soo Cho
1Department of Pediatrics, Sung Ae General Hospital
2Department of Pediatrics, Sung Ae General Hospital
3Department of Pediatrics, Sung Ae General Hospital
4Department of Pediatrics, Sung Ae General Hospital
5Department of Pediatrics, Kyunghee University, College of Medicine
Share :  
ABSTRACT
Purpose : We investigated the incidence and predisposing factors of pulmonary embolism in minimal change nephrotic syndrome(MCNS).
Methods : Lung perfusion scan using 99mTC-MAA were done on 14 patients who were diagnosed to minimal change nephrotic syndrome. Group h: Five patients who had perfusion defects on scan, Group B; Nine patients who had no perfusion defect on scan. Between the two groups, the differences of platelet number, hematocrits, albumin, cholesterol, triglyceride, proteinuria were evaluated.
Results : Five patients were found to have perfusion defect consistent with pulmonary embolism($35.7%$). However, there were minimal or no respiratory symptoms and signs. In our laboratory studies, the mean proteinuria on admissions was $676{pm}31;mg/m2/hr$ in the group with pulmonary embolism, and $313{pm}28;mg/m2/hr$ in the group without pulmonary embolism. There were more severe proteinuria in group with pulmonary embolism(P<0.05). The mean platelet count at early stage of remission after steroid treatment was $746,600{pm}280,000/mm3$ in the group with pulmonary embolism, $511,890{pm}90,000/mm3$ in the group without pulmonary embolism. There were significant difference of platelet count between the two groups(P<0.01). In patients with pulmonary embolism, there were more higher and sustained increasement of platelet count. All cases of pulmonary embolism were treated with dipyridamole(5 mg/kg). In 4 cases the perfusion defects were improved in two weeks, however, one case showed persistent perfusion defect after 1 month.
Conclusion : Our study suggested that pulmonry embolism might be one of tile major complications in childhood MCNS The occurrence rate was correlated with severity of proteinuria before treatment and sustained increasement of platelet counts in early remission state after steroid treatment. Therefore, the scintigraphic pulmonary perfusion study is mandatory in childhood MCNS, especially in the high risk patients, such as the patients with severe proteinuria and sustained increasement of platelet count. (J Korean Soc Pediatr Nephrol 2001;5 : 100-8)
Key words: Minimal change nephrotic syndrome | Pulmonary embolism
Editorial Office
124 Bukbyunjeung-ro, Kimpo, Jesewoong 2-103, Gyeonggi-do 10098, Republic of Korea
TEL : +82-31-987-5963   FAX : +82-31-987-5967   E-mail : chikd.editor@gmail.com or ckdeditor@kspn.org

Copyright© Korean Society of Pediatric Nephrology. All rights reserved.                powerd by m2community
About |  Browse Articles |  Current Issue |  For Authors and Reviewers