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Journal of the Korean Society of Pediatric Nephrology 1999;3(1): 20-26.
반복적 부동화 스트레스가 흰쥐 신장의 말초성 benzodiazepine 수용체에 미치는 영향
박용훈, 문한구, 신손문, 이은주, 이은실, 하정희
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 약리학교실
3영남대학교 의과대학 약리학교실
4영남대학교 의과대학 약리학교실
5영남대학교 의과대학 약리학교실
6영남대학교 의과대학 약리학교실
Effects of Repeated Immobilization Stress on the Renal Peripheral Benzodiazepine Receptor in Rats
Yong Hoon Park, Han Ku Moon, Son Moon Shin, Eun Ju Lee, Eun Sil Lee, Jeoung-Hee Ha
1Department of Pediatrics and College of Medicine, Yeungnam University
2Department of Pharmacology and College of Medicine, Yeungnam University
3Department of Pharmacology and College of Medicine, Yeungnam University
4Department of Pharmacology and College of Medicine, Yeungnam University
5Department of Pharmacology and College of Medicine, Yeungnam University
6Department of Pharmacology and College of Medicine, Yeungnam University
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ABSTRACT
Purpose : Several modulatory factors for renal peripheral benzodiazepine receptor (PBR) has been reported, but their physiological significance remains elusive. Tissue-specific, stress-induced down-regulation of renal PBR coupled with the pharmacological stimulation of these effects by angiotensin II suggested that physiological significance of renal PBR may be related to the pathophysiology of stress-induced hypertension. The boderline hypertensive rat (BHR) has been used extensively to study the interaction of environmental factors, such as stress and blood pressure. The BHR is the first-generation progeny of a cross between the spontaneously hypertensive rat and the control Wistar-Kyoto rat. The pathogenesis of stress induced hypertension in this model is not demonstrated well. Methods In this study, BHR (male, 150-200 g) and Sprague-Dawley (SD, male, 150-200 g) rats were treated by repeated immobilization to induce anxiety. We used plus-maze performance to observe the level of anxiety by measuring percent open crosses and percent time in open.
Results : Percent open crosses and percent time in open in BHR were lower than in SD rats (P<0.05). Receptor densities of renal PBR in BHRs were significantly lower than those of SDs (P<0.05). We also observed that the renal PBR was upregulated in the repeatedly stressed (immobilization, 2 hours daily, for 2 weeks) rats, both in the BHR and SD. However, the density of renal PBR in the stressed BHR was still lower than that of stressed SD. Renal PBR has been suggested to be an important organs which Is responsible for the production of cholesterol-derived products during stress. Conrlusion : From these results, it can be summarized that the lowed density of renal PBR may be involved in the pathogeneis of stress-induced hypertension.
Key words: Peripheral bezodiazepine receptor | Stress-indeced hypertension
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