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Journal of the Korean Society of Pediatric Nephrology 1998;2(2): 133-137.
가와사끼병과 특발성 혈소판 감소성 자반증 환아에서 고용량 정주용 면역글로불린의 신독성 유무
정지아, 김혜순, 서정완, 이승주
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 소아과학교실
3이화여자대학교 의과대학 소아과학교실
4이화여자대학교 의과대학 소아과학교실
Renal Toxicity of High-dose Intravenous Immunoglobulin in Children with Kawasaki Disease and Idiopathic Thrombocytopenic Purpura
Ji Ah Jung, Hye Soon Kim, Jeong Wan Seo, Seung Joo Lee
1Department of Pediatrics, Ewha Woman University, College of Medicine
2Department of Pediatrics, Ewha Woman University, College of Medicine
3Department of Pediatrics, Ewha Woman University, College of Medicine
4Department of Pediatrics, Ewha Woman University, College of Medicine
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ABSTRACT
Purpose : To investigate renal toxicity of high-dose intravenous immunoglobulin(IVIG) in children with Kawasaki disease and idiopathic thrombocytopenic purpura.
Methods : 23 children with Kawasaki disease and 7 children with idiopathic thrombocytopenic purpura who were treated with high-dose IVIG(2 g/kg) were evaluated for the change of urine output, blood urea nitrogen(BUN), serum creatinine(Scr), creatinine clearance(Ccr), tubular reabsorption of phosphorus(TRP), fractional excretion of sodium(FENa), 24hour urine ${beta}_2$-microglobulin/creatinine(${beta}_{2}MG/cr$) ratio and urine microalbumin/creatinine(MA/cr) ratio at post-IVIG 1 and 3 day.
Results : There was no significant change of urine output, BUN, Scr, Ccr, TRP, 24hour urine ${beta}_{2}MG/cr$ and MA/cr ratio after high-dose IVIG treatment. Transient increase of FENa at post-IVIG 1 day was the only significant change.
Conclusion : There was no significant renal toxicity of high-dose IVIG in children with Kawasaki disease and idiopathic thrombocytopenic purpura who had normal renal function.
Key words: IVIG | Renal Toxicity
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